TY - JOUR AU - Tіupka, T. AU - Minaіeva, A. PY - 2017/09/29 Y2 - 2024/03/29 TI - Pharmacological studies of a new derivative of 2-oxoindoline JF - Reports of Vinnytsia National Medical University JA - Rep. of Vinnytsia Nation. Med. Univ. VL - 19 IS - 2 SE - ORIGINAL INVESTIGATIONS DO - UR - https://reports-vnmedical.com.ua/index.php/journal/article/view/229 SP - 318-321 AB - The anti-exudative and antimicrobial activity of a new potential anti-inflammatory agent the methyl ester of N-[(2- oxoindolinylidene-3)-2-oxyacetyl]-aminoacetic acid have been researched. It was established experimentally that the new test compound reduces carrageenan foot edema inflammation in rats by 76,7%. The research results of the antimicrobial activity demonstrate sensitivity or a high sensitivity of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Proteus vulgaris, Candida ablicans strains to the new test compound. ER -