@article{Pantyo_Fizer_Fizer_Koval_Danko_2020, title={Anti-microbial activity of heterocyclic cationic surface-active substances}, volume={24}, url={https://reports-vnmedical.com.ua/index.php/journal/article/view/721}, DOI={10.31393/reports-vnmedical-2020-24(1)-07}, abstractNote={<p><strong>Annotation. </strong>The development and rapid pace of the spread of resistance to antimicrobial agents predetermines the search for new methods of counteracting pathogenic and conditionally pathogenic microorganisms. In this context, studies of the antimicrobial activity of newly synthesized chemicals, which in the future can be considered as candidates for antiseptic and disinfectants, are relevant. The aim of the work was to determine the antimicrobial activity of new ionic associates based on the surface-active cetylpyridinium cation with respect to certain opportunistic microorganisms. The antimicrobial activity of four ionic associates based on the cetylpyridinium cation with respect to clinical isolates of E.&nbsp;coli, P.&nbsp;vulgaris, K.&nbsp;pneumonia, P.&nbsp;aeruginosa, S.&nbsp;aureus, as well as the collection test strains of S.&nbsp;aureus ATCC 25923, E.&nbsp;coli ATCC 29522 and P.&nbsp;aeruginosa ATCC 27853 was studied. Screening studies were performed by the disk diffusion method. With substances that showed an antimicrobial effect, quantitative studies were carried out by the method of serial macro-dilutions in a liquid nutrient media. Screening studies revealed the antibacterial activity of the substances against E. coli ATCC 25923, E.&nbsp;coli (clinical isolate), P.&nbsp;vulgaris and K.&nbsp;pneumonia. With these microorganisms quantitative studies were carried out with the determination of the minimum inhibitory and minimum bactericidal concentrations. The most pronounced antimicrobial activity for the investigated microflora was shown by tetraphenylborate and cetylpyridinium perchlorate. The MIC and MBC values of these substances ranged between 1.625–3.125 mmol&nbsp;/&nbsp;L and 3.125–12.5 mmol&nbsp;/&nbsp;L, respectively. The studied associates showed high antimicrobial activity against representatives of the Enterobacteriaceae family in in vitro studies. Promising is the further study of the effect of the counter-anion associates of cationic surfactants on the biofilm formation of conditionally pathogenic microorganisms.</p&gt;}, number={1}, journal={Reports of Vinnytsia National Medical University}, author={Pantyo, V. V. and Fizer, M. M. and Fizer, O. I. and Koval, G. M. and Danko, E.M.}, year={2020}, month={Feb.}, pages={36-40} }