@article{Moroz_Soni_Chichirelo-Konstantynovych_Kulias_Popovych_2019, title={Clinical and laboratory features of viral hepatitis B among HIV-patients in Zambia}, volume={23}, url={https://reports-vnmedical.com.ua/index.php/journal/article/view/631}, DOI={10.31393/reports-vnmedical-2019-23(2)-14}, abstractNote={<p>Viral hepatitis B course in HIV patients in Zambia is still bad studied. At present, the study of the influence of immunosuppression on the clinical and laboratory features of viral hepatitis B acquires a special relevance. The aim of research is to investigate clinical and laboratory features of viral hepatitis B course among HIV-patients in Zambia. Epidemiological, descriptive, serological (HBV, HIV markers), biochemical (cytolysis and cholestasis syndromes’ indicators), statistic method for determining the reliability using average errors (m), t-criterion of the probability difference of the Student) methods are used. The results show HBV/HIV-positive Zambian patients reliably differ from HBV-monoinfected ones. As well, HBV/HIV-positive patients have significantly higher indexes of asteno-vegetatic, dyspeptic syndromes, hepato- and splenomegaly, cytolysis indexes (alanine aminotransferase, lactate dehydrogenase), which are associated with increase of HIV-infection’s stage. Hepatocellular deficiency’s indicators don’t differ reliably in comparison groups. Therefore, HBV/HIV-infected patients have more severe clinical and laboratory course than HBV-monoinfected ones.</p&gt;}, number={2}, journal={Reports of Vinnytsia National Medical University}, author={Moroz, L. V. and Soni, S. Ch. and Chichirelo-Konstantynovych, K. D. and Kulias, S. M. and Popovych, O. O.}, year={2019}, month={Jun.}, pages={257-262} }