Correction of sexual dysfunction in postmenopausal women
Annotation. In the postmenopausal age, the quality of sexual life deteriorates significantly. To date, there are no effective methods for correcting sexual dysfunction (SD) in women of this age. The aim of the study was to compare the clinical efficacy of traditional drugs for menopausal hormone therapy (MHT) – tibolone and a complex drug containing 1 mg of estradiol and 5 mg of dydrogesterone for SD in postmenopausal women. 69 postmenopausal women with SD were monitored: 37 – the main group (MG), 32 – the comparison group (CG). MG women were treated a drug’s containing tibolone, 1 pill once a day. Women with CG were prescribed traditional menopausal hormone therapy (MHT) with a drug containing 1 mg of estradiol and 5 mg of dydrogesterone. The quality of sexual life was determined before treatment and 1 month after treatment using a specially designed questionnaire and menopause rating scale (MRS). Statistics were processed using LibreOffice Calc (Mozilla Public License v 2.0). Quantitative data from the two related groups (before and after treatment) were compared using the Wilcoxon signed rank test. When considering the results in an alternative form (the presence or absence of a certain feature used Fisher's angular transformation. Pairwise comparisons of groups were performed using the Mann-Whitney test at p <0,05. In the treatment of SD in women with MG there was a reduction of all symptoms; in patients with CG - improvement of only one indicator was observed. In MG, after 1month treatment of SD, the number of women satisfied with their sexual life increased 2.4 times (p<0.05), and in CG – 1.4 times (p>0.05). Significant reduction in most menopausal symptoms was observed in both groups of women after treatment. According to psychoneurological indicators and atrophic changes of the vagina, the difference between MG and CG after treatment was not detected (p>0.05). Besides, the best correction of climacteric vegetative disorders in CG was found in comparison with MG (p<0.05). In MG has been noted significant improvement in physical and mental health disorders and joint and muscle discomfort compared with СG (p <0.05). Recovery of urinary disorders during a month of therapy with MHT drugs was not observed in any group of studied women. Thus, the drug based on tibolone can be recommended for the correction of sexual dysfunction in postmenopausal women.
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