Optimization of early markers for the diagnosis of preeclampsia on the background of metabolic syndrome
Annotation. Preeclampsia remains a mysterious puzzle for clinicians and researchers who have been uncovering it for decades. The search for new modern diagnostic markers for the possibility of early prevention of this complication will facilitate the course of pregnancy and childbirth. Preeclampsia can affect 2-8% of all pregnancies. The study of angiogenic biomarkers to stratify the risk of disease is the aim of our study. Patients are divided into groups due to the severity of preeclampsia. Group I included 26 pregnant women with moderate preeclampsia, diastolic blood pressure was up to 90 m Hg, to group II – 20 pregnant women with moderate preeclampsia, the level of diastolic pressure was up to 99 m Hg. The third group included pregnant women in whom the physiological course of pregnancy without complications and concomitant extragenital pathology. Inhibin A levels were determined using a Beckmann Coulter analyzer and test system (Germany); ELISA Testkit, Access-Inhibin A Kit by Beckmann Coulter, the concentration of vitamin D in the serum of patients was determined using an analyzer and test system Immulite (Siemens AG, Germany). Statistical analysis of the obtained results was performed minus the mean value (M) and the standard error of the mean value (m). Qualitative indicators are presented in the form of %. Comparison of quantitative indicators with normal distribution was performed by Student’s t test (p<0.05), and with abnormal distribution in unrelated samples – using Mann-Whitney test (U test), comparison of relative values – using χ2 (chi) -square). A significant relationship (p=0.041) was found between inhibin A levels and the occurrence of preeclampsia. Vitamin D deficiency (24.5±1.01 ng/ml) was also found in women in the study groups. The level of placental growth factor in all women in the first trimester of pregnancy was 45.93±11.74 pg/ml, which corresponds to normal values. The mean level of insulin-like growth factor was reduced (120.87±4.12 ng/ml) compared with the control group (224.1±6.24 ng/ml). Thus, increased inhibin A, decreased IGF, and vitamin D deficiency may be a marker for a patient at risk for preeclampsia.
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