A case of Behcet’s disease in the practice of a doctor

Keywords: Behcet’s disease, etiology, diagnosis, treatment.


Annotation. The article presents a description of the observation of a patient with Behcet’s disease, a rare systemic disease. The description traces the stages of disease development, difficulties in its diagnosis, polymorphism. The publication also presents modern views on the etiology, mechanisms of occurrence, diagnosis and consequences of Behcet's disease.


[1] Abdulov, A. M., Zhuravleva, Ya. V., Abdullakhodzhaev, K. A., Gildieva, A. S., & Sobirov, S. P. (2008). Случай болезни Бехчета у 13-летней девочки [A case of Behçet’s disease in a 13-year-old girl]. Клин. дерматол. и венерол. – Klin. Dermatol. and Venereal., 5, 28-31.

[2] Adaskevich, V. P., & Katina, M. A. (2009). Болезнь Бехчета: современные аспекты [Behçet’s disease: modern aspects]. Сonsil. Med. Дерматология – Сonsil. Med. Dermatol., 2, 42-47.

[3]. Аdrianto, I., Wen, F., Templeton, A., Wiley, G., King, J. B., Lessard, C. J., … & Gaffney, P. M. (2011). Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet., 43(3), 253-258. doi: 10.1038/ng.766

[4]. Аksentijevich, I., & Zhou, Q. (2017). NF-κB pathway in autoinflammatory diseases: dysregulation of protein modifications by ubiquitin defines a new category of autoinflammatory diseases. Front Immunol., 8, 399. doi: 10.3389/fimmu.2017.00399

[5]. Alekberova, Z. S., & Lisitsyna, T. A. (2017). Болезнь Бехчета [Behçet’s disease]. В Е. Л. Насонов (Pед.). Ревматология. Российские клинические рекомендации. (c. 210-228) [In E. L. Nasonov (Ed.). Rheumatology. Russian clinical guidelines. (p. 210-228)]. Москва: ГЭОТАР-Медиа.

[6]. Alekberova, Z. S., Lisitsyna, T. A., Goloeva, R. G., & Davydova, G. A. (2019). Болезнь Бехчета: клинико-гендерные ассоциации [Behcet’s disease: clinical and gender associations]. Современная ревматология – Modern rheumatology, 13(2), 84-89. doi: 10.14412/1996-7012-2019-2-84-89

[7]. Alpsoy, E. (2016). Behçet’s disease: A comprehensive review with a focus on epidemiology, etiology and clinical features, and management of mucocutaneous lesions. J Dermatol., 43(6), 620-32. doi: 10.1111/1346-8138.13381

[8]. Golovach, I. Yu., & Egudina, E. D. (2020). Современный взгляд на этиологию, эпидемиологию и клинические проявления болезни Бехчета [A modern view on the etiology, epidemiology and clinical manifestations of Behcet’s disease]. Практикуючий лікар – Practitioner, 9(1), 34-44.

[9]. Indhumathi, S., Rajappa, M., Chandrashekar, L., Ananthanarayanan, P. H., Thappa, D. M., & Negi, V. S. (2015). TNFAIP3 and TNIP1 polymorphisms confer psoriasis risk in South Indian Tamils. Br J iomed Sci., 72(4), 168-173. doi: 10.1080/09674845.2015.11665748

[10]. Hatemi, G., Seyahi, E., Fresko, I., Talarico, R., & Hamuryudan V. (2018). One year in review 2018: Behcet’s syndrome. Clin Exp Rheumatol., 36(6, 115), 13-27. PMID: 30582516

[11] Kato, M., Sanada, M., Kato, I., Sato, Y., Takita, J., Takeuchi, K., … & Ogawa, S. (2009). Frequent inactivation of A20 in B-cell lymphomas. Nature, 459, 712-716. doi: 10.1038/nature07969

[12] Khamitov, R. F., Palmova, L. Yu., Yakupova, Z. N., & Khasanova, E. R. (2013). Болезнь Бехчета в терапевтической клинической практике [Behcet’s disease in therapeutic clinical practice]. Казанский медицинский журнал – Kazan Medical Journal, 94(4), 545-548.

[13] Kozlova, A. L., Burlakov, V. I., & Shcherbina, A. Yu. (2019). Аутовоспалительные заболевания [Autoinflammatory diseases]. Педиатрия. Журнал им. Г.Н. Сперанского – Pediatrics. Journal named after G.N. Speransky, 98(3), 227-234.

[14] Lisitsyna, T. A., Alekberova, Z. S., Goloeva, R. G., & Davydova, G. A. (2019). Болезнь Бехчета: клинические проявления, современные принципы диагностики и терапии [Behcet’s disease: clinical manifestations, modern principles of diagnosis and therapy]. Научно-практическая ревматология – Scientific and practical rheumatology, 57(5), 553-563. doi.org/10.14412/1995-4484-2019-553-563

[15] Moaaz, M., & Mohannad, N. (2016). Association of the polymorphisms of TRAF1 (rs10818488) and TNFAIP3 (rs2230926) with rheumatoid arthritis and systemic lupus erythematosus and their relationship to disease activity among Egyptian patients. Cent Eur J Immunol., 41(2), 165-175. doi: 10.5114/ceji.2016.60991

[16] Musone, S. L., Taylor, K. E., Lu, T. T., Nititham, J., Ferreira, R. C., Ortmann, W., … & Lindsey, A. (2008). Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nat Genet., 40(9), 1062-1064. doi: 10.1038/ng.202

[17] Nair, R. P., Duffin, K. C., Helms, C., Ding, J., Stuart, P. E., Goldgar, D., … & Abecasis, G. R. (2009). Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappa B pathways. Nat Genet., 41(2), 199-204. doi: 10.1038/ng.311

[18] Nugumanova, A. M., & Samoilov, A. N. (2012). Клинический случай болезни Бехчета в практике офтальмолога [Clinical case of Behcet’s disease in the practice of an ophthalmologist]. Практ. мед. – Practical medicine, 2(4), 128-130.

[19] Potrokhova, E. A., Baleva, L. S., Sipyagina, A. E., Yakusheva, E. N., & Safonova, M. P. (2021). Бехчета-подобный cемейный аутовоспалительный синдром: клинический случай и обзор литературы [Behcet-like familial autoinflammatory syndrome: a case report and a review of the literature]. Рос вестн перинатол и педиатр. – Russian Bulletin of Perinatology and Pediatrics, 66(2), 110-115. doi.org/10.21508/1027-4065-2021-66-2-110-115

[20] Rumyantsev, A. G., & Demina, O. M. (2020). Аутовоспалительные заболевания: современная концепция патогенеза, клиники и диагностики [Autoinflammatory diseases: modern concept of pathogenesis, clinic and diagnostics]. Педиатрия. Журнал им. Г.Н. Сперанского – Pediatrics. Journal named after G.N. Speransky, 99(3), 211-219.

[21] Schmitz, R., Hansmann M. L., Bohle V., Martin-Subero J. I., Hartmann S., Mechtersheimer, … & Küppers, R. (2009). TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J Exp Med., 206(5), 981-989. doi: 10.1084/jem.20090528

[22] Seyahi, E. (2019). Phenotypes in Behcet’s syndrome. Intern Emerg Med., 14(5), 677-89. doi: 10.1007/s11739-019-02046-y

[23] Takagi, M., Ogata, S., Ueno, H., Yoshida, K., Yeh, T., Hoshino A., … & Tomohiro Morio (2017). Haploinsufficiency of TNFAIP3 (A20) by Germline Mutation Is Involved in Autoimmune Lymphoproliferative Syndrome. Allergy Clin Immunol., 139(6), 1914-1922. doi: 10.1016/j.jaci.2016.09.03

[24] Yazici, Y., & Yazici, H. (2010). Behcet’s Syndrome. Springer New York Dordrecht Heidelberg London. ISBN: 978-1-4419-5641-5

[25] Zhou, Q., Wang, H., Schwartz, D. M., Stoffels, M., Park, Y. H., Zhang, Y., Ling J., & Yang J. (2016). Loss-of-unction mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset auto-inflammatory disease. Nature Genet., 48, 67-73. doi: 10.1038/ng.3459
How to Cite
Lysytsia, Y. N., Pypa, L. V., & Svistilnik, R. V. (2022). A case of Behcet’s disease in the practice of a doctor. Reports of Vinnytsia National Medical University, 26(1), 44-48. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2022-26(1)-08