Informativeness of laboratory methods of research of pregnant women with chronic inflammatory bowel disease


Keywords: inflammatory bowel diseases, laboratory methods, pregnancy.

Abstract

Annotation. The aim of the work is to demonstrate the importance of laboratory parameters in pregnant with chronic inflammatory bowel disease. The examined patients were divided into the main group (ulcerative colitis, n=40) and the control group (practically healthy women, n=30). The formation of observation groups was carried out by methods of continuous and selective analysis. The indicators of vasculo-endothelial growth factor (VEGF), serum levels of vitamin D, homocysteine, markers of neutrophilic intestinal inflammation (serum levels of tumor necrosis factor α and interleukin-4 were studied). Database formation and all calculations were performed using the software packages STATISTICA6.1 (№АХХR910F374605FA) and MedCalc (version 17.7.7, MedCalcSoftware). Statistical processing of quantitative data included the calculation of the mean and standard error of the mean (± m) using parametric criteria (in the case of a normal distribution law) or a nonparametric Mann-Whitney test (if the distribution law differs from the normal one). In the analysis of the informativeness of laboratory methods, it was found that women with chronic inflammatory bowel disease were characterized by: increased levels of fecal calprotectin, proinflammatory cytokines TNFα and interleukin-4, homocysteine. The analysis of markers of endothelial dysfunction in pregnant women with COPD was diagnosed with a significant increase in serum levels of vasculo-endothelial growth factor and an increase in microalbuminuria, which allowed to talk about the association of ulcerative colitis with the development of gestational endotheliopathy in such women.

References

[1] Bentesa, C. M., Resendea, M., Miranda, H., Netto, C. C., & Marinheiro, L. P. F. (2017). Can Vitamin D supplementation alone effective to increase a physical fitness levels in post-menopausal women with metabolic disorders? Diabetes & Metabolic Syndrome, 12(1), 65-68. doi: 10.1016/j.dsx.2017.08.010

[2] Body, C., & Christie, J. A. (2016). Gastrointestinal diseases in pregnancy: nausea, vomiting, hyperemesis gravidarum, gastroesophageal reflux disease, constipation, and diarrhea. Gastroenterology Clinics, 45(2), 267-283. doi: 10.1016/j.gtc.2016.02.005

[3] Bressler, B., Marshall, J. K., Bernstein, C. N., Bitton, A., Jones, J., Leontiadis, G. I., … & Feagan, B. (2015). Clinical practice guidelines for the medical management of nonhospitalized ulcerative colitis: the Toronto consensus. Gastroenterology, 148(5), 1035-58.e3 doi: 10.1053/j.gastro.2015.03.001

[4] Coppede, F., Stoccoro, A., Tannorella, P., & Migliore, L. (2019). Plasma Homocysteine and Polymorphisms of Genes Involved in Folate Metabolism Correlate with DNMT1 Gene Methylation Levels. Metabolites, 9(12), E298. doi: 10.3390/metabo9120298

[5] Ferstl, F. S., Kitay, A. M., Trattnig, R. M., Alsaihati, A., & Geibel, J. P. (2016). Secretagogue-dependent and-independent transport of zinc hydration forms in rat parietal cells. Pflügers Archiv-European Journal of Physiology, 468(11-12), 1877-1883. doi: 10.1007/s00424-016-1889-3

[6] Kammerlander, H., Nielsen, J., Kjeldsen, J., Knudsen, T., Gradel, K. O., Friedman, S., & Norgard, B. M. (2018). Fecal calprotectin during pregnancy in women with moderate-severe inflammatory bowel disease. Inflamm Bowel Dis., 24(4), 839-48. doi: 10.1093/ibd/izx055

[7] Kiryushenkov, P. A. (2014). Гематомы на ранних сроках беременности. Диагностика и прогнозирование [Hematomas in early pregnancy]. Невынашивание беременности – социальная проблема, медицинское решение, Материалы IV науч.-практ. конф. [Diagnostics and forecasting. Miscarriage is a social problem, a medical solution, Materials of the IV scientific-practical conference]. Москва – Moscow.

[8] Lin, K., Martin, C., Dassopoulos, T., Esposti, S. D. D., Wolf, D. C., Beaulieu, D. B., & Mahadevan, U. (2014). Pregnancy outcomes amongst mothers with inflammatory bowel disease exposed to systemic corticosteroids: results of the PIANO registry [abstract]. Gastroenterology, 146(5), 146. DOI:10.1016/S0016-5085(14)60002-0

[9] Mahadevan, U., Vermeire, S., Lasch, K., Abhyankar, B., Bhayat, F., Blake, A., & Dubinsky, M. (2017). Vedolizumab exposure in pregnancy: outcomes from clinical studies in inflammatory bowel disease. Aliment Pharmacol Ther., 45(7), 941-50. doi: 10.1111/apt.13960

[10] McConnell, R. A., & Mahadevan, U. (2016). Pregnancy and the patient with inflammatory bowel disease: fertility, treatment, delivery, and complications. Gastroenterol Clin North Am., 45(2), 285-301. doi: 10.1016/j.gtc.2016.02.006

[11] Moens, A., van Hoeve, K., Humblet, E., Rahier, J-F., Bossuyt, P., Dewit, S., … & Ferrante, M. (2019). Belgian IBD Research and Development group (BIRD). Outcome ofpregnancies in female patients with inflammatory bowel diseases treated with vedolizumab. J Crohns Colitis, 13(1), 12-8. doi: 10.1093/ecco-jcc/jjy142

[12] Oleksienko, I. V. (2021). Соціально-анамнестичний та клінічний аналіз вагітних із виразковим колітом [Socio-anamnestic and clinical analysis of pregnant women with ulcerative colitis]. Вісник Вінницького національного медичного університету – Reports of Vinnytsia National Medical University, 1(25), 65-69. DOI: 10.31393/reports-vnmedical-2020-25(1)-12

[13] Pereira-Santos, M., Costa, P. R., Assis, A. M., Santos, C. A. S. T., & Santos, D. B. (2015). Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obesity Reviews, 16(4), 341-349. doi: 10.1111/obr.12239

[14] Rahsepar, M., Mahjoub, S., Esmaeilzadeh, S., Kanafchian, M., & Ghasemi, M. (2017). Evaluation of vitamin D status and its correlation with oxidative stress markers in women with polycystic ovary syndrome. Int J Reprod BioMed., 15(6), 345-350. PMID: 29202122

[15] Restellini, S., Biedermann, L., Hruz P., Mottet, C., Moens, A., Ferrante, M., & Schoepfer, A. M. (2020). Update on the management of inflammatory bowel disease during pregnancy and breastfeeding. Digestion, 101(1), 27-42. doi: 10.1159/000502886

[16] Saijo, Y., Sata, F., Yamada, H., Konodo, T., Kato, E. H., Kataoka, S., … & Kishi, R. (2004). Interleukin-4 gene polymorphism is not involved in the risk of recurrent pregnancy loss. Am J Reprod. Immunol., 52(2), 143-146. doi: 10.1111/j.1600-0897.2004.00193.x

[17] Schmidinger, M. (2013). Understanding and managing toxicities of vascular endothelial growth factor (VEGF) inhibitors. EJC Suppl., 11(2), 172-91. doi: 10.1016/j.ejcsup.2013.07.016

[18] Tervaert, T. W., Mooyaart, A. L., Amann, K., Cohen, A. H., Cook, H. T., Drachenberg, C. B., … & Bruijn, J. A. (2010). On behalf of the Renal Pathology Society. Pathologic Classification of Diabetic Nephropathy. J Am Soc Nephrol., 21(4), 556-563. DOI: https://doi.org/10.1681/ASN.2010010010

[19] Zhang, D., Wen, X., Wu, W., Guo, Y., & Cui, W. (2015). Elevated homocysteine level and folated eficiency associated with in creased overallriskofcarcinogenesis: meta-analysisof 83 case-controlstudiesinvolving 35,758 individuals. PLoSOne, 10(5), e0123423. doi: 10.1371/journal.pone.0123423
Published
2021-09-23
How to Cite
Bulavenko, O. V., Oleksiienko, I. V., Prolygina, I. V., Balabueva, S. V., & Tarasiuk, S. A. (2021). Informativeness of laboratory methods of research of pregnant women with chronic inflammatory bowel disease. Reports of Vinnytsia National Medical University, 25(3), 469-473. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2021-25(3)-22