Testing methods for surgical treatment of endometrial cancer

Keywords: endometrial cancer, laparoscopy, laparotomy, lymphodissection, rapid surgery.


Annotation. The urgency of the study is due to an increase in the incidence (more than 50%) of newly diagnosed uterine endometrial cancer, especially among young people. The main method of treatment for stage I-II endometrial cancer remains surgery. The study aimed to identify possible cytological conversion during laparoscopic procedures. The main method of research was a non-randomized, prospective cohort study with subsequent observation of the duration of hospitalization and 30 days after discharge for the period from 2010 to 2019. The duration of hospitalization was estimated, while in the perioperative period and within 30 days after discharge – the presence of postoperative complications. A total of 812 patients with stage I-IV endometrial cancer were analyzed, with a mean age of 52±5 years (25 to 75 years). The first group included patients who underwent laparotomy, the second – laparoscopic surgery. The presence of metastases and recurrences was confirmed by morphological, radiological, echoscopic and clinical methods. Standard methods of descriptive statistics were used for data processing; in particular, the average values were calculated with their standard errors when using the standard Student’s t-test at p<0.05 using Microsoft Excel software packages. Conclusions were made about the volume and type of surgery, taking into account the histological type of tumor, lymphovascular invasion, clinical stage, presence or absence of obesity and other comorbidities that may affect metabolism, life history and the presence of surgery. The obtained data confirm the safety of laparoscopic hysterectomy for women with stage I endometrial cancer. However, there are no data on whether laparoscopy can lead to intra-abdominal dissemination of tumor cells.


[1] Bouwman, F., Smits, A., Lopes, A., Das, N., Pollard, A., Massuger, L., & Galaal, K. (2015). The impact of BMI on surgical complications and outcomes in endometrial cancer surgery – An institutional study and systematic review of the literature. Gynecologic Oncology, 139(2), 369-376. doi: 10.1016/j.ygyno.2015.09.020

[2] Galaal, K., Bryant, A., Fisher, A. D., Al-Khaduri, M., Kew, F., & Lopes, A. D. (2018). Laparoscopy versus laparotomy for the management of early stage endometrial cancer. Cochrane Database of Systematic Reviews, 9, CD006655. doi: 10.1002/14651858.CD006655.pub2

[3] Gavrish, Yu. E., Berlev, I. V., & Artemieva, A. S. (2017). Uterine cancer in older women: What are its distinguishing characteristics? Tumors of the Female Reproductive System, 13(2), 56-60.

[4] Koskas, M., Jozwiak, M., Fournier, M., Vergote, I., Trum, H., Lok, Ch., & Amant, F. (2016). Long-term oncological safety of minimally invasive surgery in high-risk endometrial cancer. European Journal of Cancer, 65, 185-191. doi: 10.1016/j.ejca.2016.07.001

[5] Monterossi, G., Ghezzi, F., Vizza, E., Zannoni, G. F., Uccella, S., Corrado, G., & Fanfani, F. (2017). Minimally invasive approach in type II endometrial cancer: Is it wise and safe? Journal of Minimally Invasive Gynecology, 24(3), 438-445. doi: 10.1016/j.jmig.2016.12.022

[6] Morice, P., Leary, A., Creutzberg, C., Abu-Rustum, N., & Darai, E. (2016). Endometrial cancer. Lancet, 387(10023), 1094-1108. doi: 10.1016/S0140-6736(15)00130-0

[7] Polan, R. M., Rossi, E. C., & Barber, E. L. (2019). Extent of lymphadenectomy and postoperative major complications among women with endometrial cancer treated with minimally invasive surgery. American Journal of Obstetrics and Gynecology, 220(3), 263.e1-263.e8. doi: 10.1016/j.ajog.2018.11.1102

[8] Uccella, S., Bonzini, M., Palomba, S., Fanfani, F., Ceccaroni, M., Seracchioli, R., & Ghezzi, F. (2018). Impact of obesity on surgical treatment for endometrial cancer: A multicenter study comparing laparoscopy vs open surgery, with propensity-matched analysis. Journal of Minimally Invasive Gynecology, 23(1), 53-61. doi: 10.1016/j.jmig.2015.08.007

[9] Vardar, M. A., Gulec, U. K., Guzel, A. B., Gumurdulu, D., Khatib, G., & Seydaoglu, G. (2019). Laparoscopic surgery for low, intermediate and high-risk endometrial cancer. Journal of Gynecologic Oncology, 30(2), e24. doi: 10.3802/jgo.2019.30.e24
How to Cite
Movchan, O. M., SvintsitskіyV. S., & Bublieva, O. I. (2021). Testing methods for surgical treatment of endometrial cancer. Reports of Vinnytsia National Medical University, 25(2), 301-304. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2021-25(2)-20