25-hydroxycholecalciferol content in children with different form of asthma
This study found the content of 25-hydroxycholecalciferol (25(OH)D3) in the serum of children with various forms of asthma. To achieve this goal we examined 200 children with asthma, aged 6 to 18 years. The examination revealed that the total content of 25(OH)D3 in the serum of children with asthma is different from the values in healthy children and is characterized by a significant decrease in its level (p ≥ 0,01). It is noted that the contents of 25(OH)D3 differs depending on the variants of asthma, in atopic disease content of the substances was 21,12 ± 0,51 ng/ml was significantly higher than in nonatopic and mixed (19,42 ± 0 37 and 20,15 ± 0,29 ng/ml, respectively) its variants (p ≤ 0,001). Established negative relationship between average force containing interleukin 1 (rxy = - 0,560 (p = 0.041)) and 6 (rxy = - 0,351 (p = 0.044)) and the level of 25(OH)D3 in children with asthma. It is necessary to further study the appropriate level of circulating 25(OH)D3 to maintain optimal immune function, especially in patients with asthma.
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