25-hydroxycholecalciferol content in children with different form of asthma

  • A.P. Fedchishen
Keywords: bronchial asthma, children, 25-hydroxycholecalciferol


This study found the content of 25-hydroxycholecalciferol (25(OH)D3) in the serum of children with various forms of asthma. To achieve this goal we examined 200 children with asthma, aged 6 to 18 years. The examination revealed that the total content of 25(OH)D3 in the serum of children with asthma is different from the values in healthy children and is characterized by a significant decrease in its level (p ≥ 0,01). It is noted that the contents of 25(OH)D3 differs depending on the variants of asthma, in atopic disease content of the substances was 21,12 ± 0,51 ng/ml was significantly higher than in nonatopic and mixed (19,42 ± 0 37 and 20,15 ± 0,29 ng/ml, respectively) its variants (p ≤ 0,001). Established negative relationship between average force containing interleukin 1 (rxy = - 0,560 (p = 0.041)) and 6 (rxy = - 0,351 (p = 0.044)) and the level of 25(OH)D3 in children with asthma. It is necessary to further study the appropriate level of circulating 25(OH)D3 to maintain optimal immune function, especially in patients with asthma.


1. Besh, L. V. (2014, Liutyi). Nove v diahnostytsi i terapii bronkhialnoi astmy u ditei: praktychnyi pidkhid do traktuvannia naisuchasnishykh vitchyznianykh ta mizhnarodnykh uzghodzhuvalnykh dokumentiv. Zdorovia Ukrainy. Tematychnyi nomer, 16–17. [in Ukrainian].

2. Nanzer, A. M. (2013). Enhanced production of IL-17A in patients with severe asthma is inhibited by 1alpha,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion. The Journal of allergy and clinical immunology, 132(2), 297–304. doi: 10.1016/j.jaci.2013.03.037.

3. Zhang, Y., Leung, D. Y. & Goleva, E. (2014). Anti-inflammatory and corticosteroid-enhancing actions of vitamin D in monocytes of patients with steroid-resistant and those with steroid-sensitive asthma. The Journal of allergy and clinical immunology, 133, 1744–1752. doi: 10.1016/j.jaci.2013.12.004.
How to Cite
Fedchishen, A. (2017). 25-hydroxycholecalciferol content in children with different form of asthma. Reports of Vinnytsia National Medical University, 21(1(1), 88-91. Retrieved from https://reports-vnmedical.com.ua/index.php/journal/article/view/84