The role of metabolic adaptation of the functional state of circulating erythron in determining the course of traumatic disease in patients with massive blood loss in polytrauma


  • Yu. A. Tygai
  • K. G. Mikhnevich
Keywords: polytrauma, blood loss, erythrocyte transformation index, heterogeneous blood transfusion, ceruloplasmin.

Abstract

Annotation. Metabolic adaptation of the functional state of circulating erythron is an important criterion for predicting the course of traumatic disease in patients with polytrauma, which is accompanied by heavy blood loss. The aim of the study was to increase the effectiveness of treatment of patients with polytrauma with hemorrhagic shock by developing and implementing a differentiated approach to infusion and transfusion therapy, based on elucidation of the mechanisms of systemic oxygen transport in the postoperative period. The index of erythrocyte transformation index, oxygen delivery index as a leading indicator of oxygen transport system in patients of group I who received intensive therapy according to the classical algorithm, in patients of group II who were additionally prescribed ceruloplasmin solution, in patients of group III who were additionally prescribed a solution of D-fructose-1,6-diphosphate sodium salt hydrate. To determine the functional state of erythrocytes and their ability to deform, we used the method of scanning electron microscopy. Statistical data processing was performed using Student’s t-test (for n<100) at a given level of reliability p=0.95. The statistical analysis of the obtained data revealed a probable reduction in the number of doses of heterogeneous erythrocytes received by patients with high blood loss in polytrauma in patients of group II on the background of maximum ability of erythrocytes to transform while maintaining the oxygen delivery index at a satisfactory level. In the future it is planned to study the morphofunctional parameters of erythrocytes in this group of patients.

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Published
2020-12-28
How to Cite
Tygai, Y. A., & Mikhnevich, K. G. (2020). The role of metabolic adaptation of the functional state of circulating erythron in determining the course of traumatic disease in patients with massive blood loss in polytrauma. Reports of Vinnytsia National Medical University, 24(4), 689-693. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2020-24(4)-23