Cross-risks of development of bronchopulmonary dysplasia and necrotizing enterocolitis of premature neonates

  • A. V. Bolonska
  • O. Yu. Sorokina
Keywords: prematurity, neonates, bronchopulmonary dysplasia, necrotizing enterocolitis, risk factors.


Annotation. Bronchopulmonary dysplasia and necrotizing enterocolitis have become modern problems of effective care of premature neonates. These two pathologies significantly delay the discharge of a premature baby from the hospital, lead to significant economic costs and worsen the quality of life of these patients. The aim of the study was to identify controlled predictors of bronchopulmonary dysplasia, however, in the analysis of the initial status of patients obtained useful results for the parallel treatment of necrotizing enterocolitis. The study recruited 133 neonates with a gestational age of 28–32 weeks with a diagnosis of respiratory distress syndrome on the basis of two NICU in Dnipro in the period from 2016 to 2020. According to the results of the study in the structure of treatment of premature neonates there were significant risks of bronchopulmonary dysplasia: the duration of respiratory support by mechanical ventilation, non-invasive ventilation, additional oxygenation, nebulizer therapy, and for necrotizing enterocolitis – lower fluid intake, hemoglobin level in 1, 3, 7 days of life, moderate and severe asphyxia. Some of the approaches in therapy are cross-cutting, such as the prevention of anemia in respiratory distress syndrome, fluid intake differences and intensive care methods reducing the duration of respiratory support for the prevention of late neonatal sepsis, we can create an algorithm that takes into account all the risks and enhance outcome for these patients. The perspectives for future work – research of neurological status of former premature neonates and finding out predictors of cerebral palsy.


1. Aly, H. (2009). Ventilation without tracheal intubation. Pediatrics, 124 (2), 786–9. doi: 10.1542/peds.2009-0256

2. Bell, E. F., & Acarregui, M. J. (2014). Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants. Cochrane Database Syst. Rev., 12, CD000503. doi:10.1002/14651858.CD000503.pub3

3. Bonsante, F., Gouyon, J. B., Robillard, P. Y., Gouyon, B., & Iacobelli, S. (2017). Early optimal parenteral nutrition and metabolic acidosis in very preterm infants. PLoS One, 12 (11), e0186936. doi:10.1371/journal.pone.0186936

4. Crowley, P. (2007). WITHDRAWN: Prophylactic corticosteroids for preterm birth. Cochrane Database Syst Rev., 3, CD000065. doi:10.1002/14651858.CD000065.pub2

5. Dang, A. T., & Marsland, B. J. (2019). Microbes, metabolites, and the gut-lung axis. Mucosal Immunol., 12 (4), 843–850. doi: 10.1038/s41385-019-0160-6

6. DeLong, E. R., DeLong, D. M., & Clarke-Pearson, D. L. (1988). Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics, 44 (3), 837–45. Retrieved from

7. Flamant, C., & Gascoin, G. (2013). Short-term outcome and small for gestational age newborn management. J. Gynecol. Obstet. Biol. Reprod. (Paris), 42 (8), 985–95. doi: 10.1016/j.jgyn.2013.09.020

8. Gallacher, D. J., & Kotecha, S. (2016). Respiratory Microbiome of New-Born Infants. Front. Pediatrics, 4, 10. doi: 10.3389/fped.2016.00010

9. Jobe, A. H., & Bancalari, E. (2001). Bronchopulmonary dysplasia. Am. J. Respir. Crit. Care Med., 163 (7), 1723–9. doi: 10.1164/ajrccm.163.7.2011060

10. Kalliomäki, M., Kirjavainen, P., Eerola, E., Kero, P., Salminen, S., & Isolauri, E. (2001). Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J. Allergy Clin. Immunol., 107 (1), 129–34. doi: 10.1067/mai.2001.111237

11. Kassambara, A., Kosinski, M., & Biecek, P. (2020). Drawing Survival Curves using ‘ggplot2’ [Internet]. Retrieved from

12. Robin, X., Turck, N., Hainard, A., Tiberti, N., Lisacek, F., Sanchez, J-C., & Müller, M. (2011). pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics, 12 (1), 77.

13. Tsai, L. Y., Chen, Y. L., Tsou, K. I., & Mu, S. C. (2015). The impact of small-for-gestational-age on neonatal outcome among very-low-birth-weight infants. Pediatr. Neonatol., 56 (2), 101–7. doi: 10.1016/j.pedneo.2014.07.007

14. Williams, G. W., Berg, N. K., Reskallah, A., Yuan, X., & Eltzschig, H. K. (2021). Acute Respiratory Distress Syndrome: Contemporary Management and Novel Approaches During COVID-19. Anesthesiology, 134 (2), 270–282.
How to Cite
Bolonska, A. V., & Sorokina, O. Y. (2020). Cross-risks of development of bronchopulmonary dysplasia and necrotizing enterocolitis of premature neonates. Reports of Vinnytsia National Medical University, 24(4), 611-617.