BNP: phenotypic features of plasma concentration of biomarkers through the prism of sexual dimorphism


  • L. M. Sursaieva
  • V. M. Zhebel
  • Yu. P. Pashkova
  • L. V. Kulchevich
  • O. K. Shevchuk
Keywords: cardiovascular disease, BNP gene, polymorphic alleles, natriuretic peptide, plasma levels, overweight, BMI.

Abstract

Annotation. The aim of the study is to clarify the borderline levels of plasma concentration of BNP (B-type natriuretic peptide), with the carriage of polymorphic variants of the BNP gene in persons without cardiovascular pathology in the Podolsk region of Ukraine. Using general clinical, instrumental and laboratory methods, 67 postmenopausal women and 79 men 40–60 years old without signs of cardiovascular pathology were examined. BNP gene genotyping was performed by polymerase chain reaction. Plasma concentrations of natriuretic peptide were determined by plate solid-phase enzyme immunoassay. Mathematical processing was carried out on a personal computer using the standard statistical package Statistica 10.0. It has been established that both female and male residents of the Podolsk region of Ukraine have the same frequency of distribution of polymorphic variants of the BNP gene. Plasma concentrations of natriuretic peptide are determined by gender characteristics and are significantly higher in women: 38.32±0.65 pg/ml versus 21.74±0.50 pg/ml. in men (p<0.05). Moreover, in women, BMI is inversely correlated with the level of BNP in blood plasma.

References

1. Voronkov, L. H., Berezin, O. Ye., Voronkov, L. H., Berezin, O. Ye., Havrylenko, T. I., Zharinova, V. Yu. … & Tseluiko, V. Y. (2019). Biolohichni markery ta yikh zastosuvannia pry sertsevii nedostatnosti. Konsensus Vseukrainskoi asotsiatsii kardiolohiv Ukrainy, Vseukrainskoi asotsiatsii fakhivtsiv iz sertsevoi nedostatnosti ta Ukrainskoi asotsiatsii fakhivtsiv z nevidkladnoi kardiolohii [Biological markers and their use in heart failure. Consensus of the All-Ukrainian Association of Cardiologists of Ukraine, the All-Ukrainian Association of Heart Failure Specialists and the Ukrainian Association of Emergency Cardiology Specialists]. Ukrainskyi kardiolohichnyi zhurnal – Ukrainian Journal of Cardiology, 26 (2), 11–22. http://doi.org/10.31928/1608-635X-2019.2.1122

2. Helsinska deklaratsiia Vsesvitnoi Medychnoi Asotsiatsii [Helsinki Declaration of the World Medical Association]. (2010). Morfolohiia – Morphology, 4 (2), 65–68. Vziato z http://nbuv.gov.ua/UJRN/Morphology_2010_4_2_10

3. Markel, A. L. (2018). Genetika i patofiziologiya nizkoreninovoy arterialnoy gipertonii [Genetics and pathophysiology of low-root arterial hypertension]. Vavilovskiy zhurnal genetiki i selektsii – Vavilov Journal of Genetics and Breeding, 22 (8), 1000–1008. DOI 10.18699/VJ18.443

4. Pashkova, Yu. P., & Zhebel, V. M. (2015). Osoblyvosti strukturnoi orhanizatsii hena mozkovoho natriiuretychnoho peptydu ta riven yoho plazmovoi kontsentratsii u cholovikiv, meshkantsiv Podilskoho rehionu [Peculiarities of structural organization of brain natriuretic peptide gene and level of its plasma concentration in men, inhabitants of Podolsk region]. Biomedical and Biosocial Anthropology, 25, 12–16. Vziato z http://nbuv.gov.ua/UJRN/bba_2015_25_5

5. Pashkova, Yu. P., Zhebel, N. V., Antomonov, M. Yu., Sakovych, O. O., Starzhynska, O. L., Zhebel, V. M., … & Syvak, V. H. (2015). Patent Ukrainy 112123. №a201500795. Sposib prohnozuvannia ryzyku rozvytku khronichnoi sertsevoi nedostatnosti na tli hipertonichnoi khvoroby u cholovikiv 40-60 rokiv [Patent of Ukraine 112123. 201a201500795. A method for predicting the risk of developing chronic heart failure on the background of hypertension in men 40-60 years]. Kyiv: Derzhavne patentne vidomstvo Ukrainy.

6. Yunkerov, V. I., & Grigorev, S. G. (2002). Matematiko-statisticheskaya obrabotka dannykh meditsinskikh issledovaniy [Mathematical and statistical processing of medical research data]. Sankt-Peterburg: Voenno-med. akad.

7. Baldassarre, S., Fragapani, S., Panero, A., Fedele, D., Pinach, S., Lucchiari, M., … & Bruno, G. (2017). NTproBNP in insulin-resistance mediated conditions: overweight/ obesity, metabolic syndrome and diabetes. The population-based Casale Monferrato Study. Cardiovascular Diabetology, 16 (1), 119. doi: 10.1186/s12933-017-0601-z

8. Christopher R. de Filippi, and Stephen L. Seliger (2015). Natriuretic Peptide and Cardiovascular Risk: Is It About “U”? Journal of the American Heart Association, 4 (5). doi.org/10.1161/JAHA.115.002086

9. Clerico, A., Masotti, S., Musetti, V., & Passino, C. (2019). Pathophysiological mechanisms determining sex differences in circulating levels of cardiac natriuretic peptides and cardiac troponins. J. Lab. Precis. Med., 4 (8) doi: 10.21037/jlpm.2019.01.03

10. Hamada, M., Shigematsu, Y., Takezaki, M., Ikeda, S., & Ogimoto, A. (2017). Plasma levels of atrial and brain natriuretic peptides in apparently healthy subjects: Effects of sex, age, and hemoglobin concentration. Int. J. Cardiol., 228, 599–604. doi: 10.1016/j.ijcard.2016.11.197

11. Kim, H. L., Kim, M.-A., Choi, D.-Ju, Han, S., Jeon, E.-S., Cho, M.-C., … & Ryu, K.-H. (2017). Gender Difference in the Prognostic Value of N-Terminal Pro-B Type Natriuretic Peptide in Patients With Heart Failure. A Report From the Korean Heart Failure Registry (KorHF). Circulation Journal, 81 (9), 1329–1336. DOI: 10.1253/circj.CJ-16-1345

12. Laslett, L. J., Alagona, P. Jr., Clark, B. A. III, Drozda Jr, J. P., Saldivar, F., Wilson, S. R., … & Hart, M. (2012). The worldwide environment of cardiovascular disease: prevalence, diagnosis, therapy, and policy issues. A report from the American College of Cardiology. J. Am. Coll Cardiol., 60 (25), 1–49. doi: 10.1016/j.jacc.2012.11.002

13. Mendis, S., Puska, P., Norrving, B. (Ed.). (2014). Global Atlas on Cardiovascular Disease Prevention and Control. World Health Organization, Geneva 2011. http://whqlibdoc.who.int/publications/2011/9789241564373_eng.pdf?ua=1

14. Mingels, A. M. A., & Kimenai, D. M. (2018). Sex-related aspects of biomarkers in cardiac disease. Adv. Exp. Med. Biol., 1065, 545–64. https://doi.org/10.1007/978-3-319-77932-4_33

15. Mueller, С., McDonald, K., de Boer, R. A., Maisel, A., Cleland, J. G. F., Kozhuharov, N. … & Januzzi Jr, J. L. (2019). Heart Failure Association of the European Society of Cardiology practical guidance on the use of natriuretic peptide concentrations. European Journal of Heart Failure, 21 (6), 715–731. https://doi.org/10.1002/ejhf.1494

16. Redfield, M. M., Rodeheffer, R. J., Jacobsen, S. J., Mahoney, D. W., Bailey, K. R., & Burnett Jr, J. C. (2002). Plasma brain natriuretic peptide concentration: impact of age and gender. Journal of the American College of Cardiology, 40 (5), 976–982. doi: 10.1016/s0735-1097(02)02059-4

17. Sebastiani, P., Thyagarajan, B., Sun, F., Honig, L. S., Schupf, N., Cosentino, S., … & Perls, T. T. (2016). Age and sex distributions of age-related biomarker values in healthy older adults from the Long Life Family Study. J. Am. Geriatr. Soc., 64 (11), 189–194. https://doi.org/10.1111/jgs.14522

18. Suthahar, N., Meijers, W. C., Ho, J. E., Gansevoort, R. T., Voors, A. A., van der Meer, P., … & de Boer, R. A. (2018). Sex specific associations of obesity and N-terminal pro-B-type natriuretic peptide levels in the general population. Eur. J. Heart Failure, 20 (8), 1205–1214. https://doi.org/10.1002/ejhf.1209

19. Taki, M., Ishiyama, Y., Mizuno, H., Komori, T., Kono, K., Hoshide, S., Kario, K. (2018). Sex difference in the prognostic power of Brain Natriuretic Peptide and N-terminal pro-Brain Natriuretic Peptide for cardiovascular events – The Japan Morning Surge – Home Blood Pressure Study. Circ. J., 82 (8), 2096–2102. doi: 10.1253/circj.CJ-18-0375

20. Tanase, D. M., Radu, S., Al Shurbaji, S., Baroi, G. L., Costea, C. F., Turliuc, M. D., … & Floria, M. (2019). Natriuretic Peptides in Heart Failure with Preserved Left Ventricular Ejection Fraction: From Molecular Evidences to Clinical Implications. International Journal of Molecular Sciences, 20 (11), 2629. https://doi.org/10.3390/ijms20112629

21. Utkin, L. V., & Zhuk, Y. A. (2016). A Genome-Wide Association Study using Pairwise Comparison Matrices. SPIIRAS Proceedings, 4 (47), 225. ISSN 2078-9599. DOI:10.15622/sp.47.12

22. Volpe, M., Rubattu, S., & Burnett, J., Jr. (2014). Natriuretic peptides in cardiovascular diseases: Current use and perspectives. Eur. Heart J., 35 (7), 419–425. doi: 10.1093/eurheartj/eht466

23. Wei, Y.-C., George, N. I., Chang, C.-W., & Hicks, K. A. (2017). Assessing sex differences in the risk of cardiovascular disease and mortality per Increment in systolic blood pressure: A systematic review and meta-analysis of follow-up studies in the United States. PLoS ONE, 12 (1), e0170218. https://doi.org/10.1371/journal.pone.0170218

24. Williams, B., Mancia, G., Spiering, W., Rosei, E. A., Azizi, M., Burnier, M., … & Desormais, I. (2018). 2018 ESC/ESH Guidelines for the management of arterial hypertension. European Heart Journal, 39 (33), 3021–3104. https://doi.org/10.1093/eurheartj/ehy339
Published
2020-12-28
How to Cite
Sursaieva, L. M., Zhebel, V. M., Pashkova, Y. P., Kulchevich, L. V., & Shevchuk, O. K. (2020). BNP: phenotypic features of plasma concentration of biomarkers through the prism of sexual dimorphism. Reports of Vinnytsia National Medical University, 24(4), 571-576. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2020-24(4)-02