Study of cerebral hemodynamics in children with small anomalies of the heart development

Keywords: children, small anomalies of heart development, ultrasound dopplerography of cerebral vessels, mitral valve prolapse, abnormally attached chords.


Annotation. Diseases of the cardiovascular system occupy a leading place in the structure of non-infectious pathology. In the literature, small abnormalities of the development of the heart are described as abnormally located trabeculae or additional chords in the left ventricle of the heart or mitral valve prolapse. At present, the problem of cerebral hemodynamic disorders in children with them is insufficiently studied in medical sources. The aim of our study was to analyze cerebral hemodynamics using ultrasound dopplerography of cerebral vessels in children with abnormally attached chords (AAC) and mitral valve prolapse (MVP). We examined 64 children with AAC and 106 patients with MVP (among whom there were 90 with MVP I degree and 16 with MVP II degree) aged from 13 to 17 years, who formed the main group. The results were compared with the data of the control group, which included 23 almost healthy children also aged 13–17 years. All children underwent ultrasound dopplerography of extra- and intracranial vessels and veins of the brain. Evaluated the average values in the form of M±m. The values of the differences between the indicators of the two samples were evaluated by Student’s parametric criterion (t) using a special program such as Microsoft Excel. In children with MVP I deg. we found a pronounced violation of blood flow in a. vertebralis on both sides with diagnostically significant (р<0,05) decrease in the mean values of systolic and diastolic blood flow indexes. The elasticity of the vessels was high relative to the control group. In children with grade II MVP, a decrease of the blood flow was observed within a. vertebralis basin, which was accompanied by a significant (р<0,05) decrease of systolic and diastolic velocities on both sides in comparison with control group. An increase (р<0,05) in systolic-diastolic index (Sd) and circulatory resistance index (Ri) was noted in both sides, indicating a simultaneous increase in the tone and elasticity of these vessels. In patients with AAC there was a decrease in systolic and diastolic velocities in the a.vertebralis on both sides with increase of Sd relative to the control group. Thus, cerebral blood flow in children with AAC and MVP is generally satisfactory. There are changes in the elastic and tonic properties of blood vessels in these children. The results of the study will be useful to narrow specialists for timely and adequate rehabilitation of patients with MARS.


1. Zaharova, I. N., Tvorogova, T. M., Stepurina, L. L., Pshenichnikova, I. I., Vorobeva, A. S., & Kuznecova, O. A. (2015). Vegetativnaya distoniya v praktike pediatra [Vegetative dystonia in the practice of a pediatrician]. Medicinskij sovet – Medical Council, 14, 98–104. Vzyato s

2. Kulniyazova, G. M., Davidovich, S. G., Sejpenova, A. N., & Sauleeva, F. S. (2015). Optimizaciya diagnostiki prolapsa mitralnogo klapana i osobennostej ego techeniya v detskom vozraste [Optimization of the diagnosis of mitral valve prolapse and features of its course in childhood]. Arhiv vnutrennej mediciny – Archive of Internal Medicine, 3 (23), 14–17. Vzyato s

3. Maidannyk, V. H., Mitiuriaieva-Korniiko, I. O., Kukhta, N. M., & Hnyloskurenko, H. V. (2017). Vehetatyvni dysfunktsii u ditei. Paroksyzmalna vehetatyvna nedostatnist: monohrafiia [Vegetative dysfunction in children. Paroxysmal vegetative insufficiency]. Kyiv: Lohos.

4. Mirzoyan, E. S., Babaev, M. V., Nelasov, N. Yu., Ajvazyan, Sh. G., & Stizhko, N. O. (2018). Ehokardiograficheskij skrining detej i podrostkov pri planovoj dispanserizacii [Echocardiographic screening of children and teenagers during routine physical examination]. Medicinskij vestnik Yuga Rossii – Medical Herald of the South of Russia, 9 (4), 67–72. doi: 10.21886/2219-8075-2018-9-4-67-72

5. Basso, C., Marra, M. P., Rizzo, S., De Lazzari M., Giorgi, B., Cipriani, A., ... & Iliceto, S. (2015). Arrhythmic mitral valve prolapsed and sudden cardiac death. Circulation, 132, 556–566. doi: 10.1161/CIRCULATIONAHA.115.016291

6. Boudoulas, K. D., & Boudoulas, H. (2013). Floppy mitral valve (FMV)/mitral valve prolapse (MVP) and the FMV/MVP syndrome: pathophysiologic mechanisms and pathogenesis of symptoms. Cardiology, 126 (2), 69–80. doi: 10.1159/000351094

7. Delling, F. N., & Vasan, R. S. (2014). Epidemiology and pathophysiology of mitral valve prolapse: new insights into disease progression, genetics, and molecular basis. Circulation, 129 (21), 2158–2170. doi: 10.1161/CIRCULATIONAHA.113.006702

8. Deng, Y., Wei, S., Hu, S., Chen, J., Tan, Z., & Yang, Y. (2015). Ehlers-Danlos syndrome type IV is associated with a novel G984R COL3A1 mutation. Mol. Med. Rep., 12 (1), 1119–1124. doi: 10.3892/mmr.2015.3488

9. Guy, T. S., & Hill, A. C. (2012). Mitral valve prolapse. Annual review of medicin, 63 (1), 277–292. doi: 10.1146/annurev-med-022811-091602

10. Narayanan, K., Uy-Evanado, A., Teodorescu, C., Nichols, G. A., Gunson, K., ... & Chugh, S. S. (2015). Mitral Valve Prolapse and Sudden Cardiac Arrest in the Community. Heart Rhythm, 13 (2), 498–503. doi: 10.1016/j.hrthm.2015.09.026

11. Nordhues, B. D., Siontis, K. C., Scott, C. G., Nkomo, V. T., Ackerman, M. J., Asirvatham, S. J., & Noseworthy, P. A. (2016). Bileaflet mitral valve prolapse and risk of ventricular dysrhythmias and death. Journal of Cardiovascular Electrophysiology, 27 (4), 463–468. doi: 10.1111/jce.12914

12. Roy, H. A., & Green, A. L. (2019). The central autonomic network and regulation of bladder function. Frontiers in neuroscience, 13, 1–10. doi: 10.3389/fnins.2019.00535
How to Cite
Kuleshov, A. V., Medrazhevskaya, Y. A., & Cherepakhyna, L. P. (2020). Study of cerebral hemodynamics in children with small anomalies of the heart development. Reports of Vinnytsia National Medical University, 24(3), 404-408.