Clinical background of cognitive disorders associated with epileptic syndrome of various genesis


Keywords: cognitive impairment, epilepsy, topical diagnosis.

Abstract

Annotation. The prevalence of cognitive impairments that have not reached the degree of dementia is 15-20%. It is known that 20% of people with intellectual disabilities, due to structural changes in the brain, can be diagnosed with epilepsy. The aim of the study was to evaluate the clinical, laboratory, and functional parameters of patients diagnosed with varying degrees of cognitive disorders in the setting of an epileptic seizure in a neurological department. A retrospective assessment was made of 211 patients with cognitive decline who had a history of epileptic seizures (with consequences of traumatic brain injury, perinatal trauma with hypoxic encephalopathy, stroke, discirculatory encephalopathy, brain tumors, arteriovenous malformations, cryptogenic and due to exogenous intoxication). To assess the patient's cognitive function, rapid tests were used: a shortened test of mental abilities - 4 (AMT-4) and a simplified MMSE test. A preliminary comparison of retrospective patients quality indicators was assessed using simple mathematical methods. It was shown a significant effect on the level of cognitive impairment of exogenous intoxication, as well as atherosclerotic changes in the vessels. Brain damage due to trauma or tumor, as the cause of a convulsive attack, showed more pronounced asthenization, lethargy, decreased criticism and intelligence in the case of right hemispheric localization. More pronounced cognitive impairments occurred with lesions in the frontal and temporal localization. So, with damage to the temporal lobe, amnestic disturbances, disorientation in time and space were characteristic. With damage to the frontal lobe - decreased attention, the occurrence of asthenic-depressive syndrome, lethargy. More pronounced speech and writing disorders, disorientation in time and space, astheno-neurotic syndrome with emotional lability were revealed in the case of damage to the left carotid system in stroke. Thus, the study of cognitive impairments in a neurological clinic is one of the important interdisciplinary problems of modern medicine.

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Published
2020-10-12
How to Cite
Symonenko, H. (2020). Clinical background of cognitive disorders associated with epileptic syndrome of various genesis. Reports of Vinnytsia National Medical University, 24(2), 266-273. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2020-24(2)-12