Analytic prognostication of sensitivity to fluoroquinolones in S. aureus, as pathogens of infectious complications in burn patients


Keywords: sensitivity, antimicrobials, S. aureus, fluoroquinolones.

Abstract

Annotation. In the research, the new data of S. aureus clinical strains’ sensitivity to fluoroquinolones is presented. The aim of the research was to carry out analytic prognosis of sensitivity to fluoroquinolones in clinical strains of S. aureus, isolated from patients with burns. Our research was carried out in 2011–2018. From patients there were isolated 204 clinical strains of S. aureus. There was studied the sensitivity of S. aureus clinical strains to such fluoroquinolones as ofloxacinum, levofloxacin, gatifloxacin. The sensitivity was carried out by means of standard qualitative disc-diffusion method on dense medium and quantitative serial dilution one. The analytical dependence of dynamic prognostic changing criteria of S. aureus clinical strains’ sensitivity to fluoroquinolones was found by means of mathematical prognostication. Prognostic mathematical models were conducted. Authenticity of every model and substantiation of the prognosis of antibiotic sensitivity of S. aureus were estimated due to determination criteria (r2). “STATISTICA 10.0”; “Matlab 7.11” programs were used. In the result of the statistical analysis of the data, obtained in research, we found decreasing sensitivity of S. aureus to ofloxacinum and levofloxacin. The sensitivity to ofloxacinum in S. aureus strains was found to be reduced the 94,12% in 2012 years to 56,2% in 2020 years.). The resulting mathematical model showed a prognostic decrease in the sensitivity of hospital strains of S. aureus to levofloxacin. A mathematical prognostic model indicated a likely improvement in staphylococcus sensitivity to gatifloxacin in 2020 (94.1%). Obtained formulas of analytical prognosis of sensitivity of S. aureus, colonizing burn surfaces in patients, proved the decreasing effectiveness of fluoroquinolones in prophylaxis and treatment of infectious complications, caused by this opportunistic pathogen. That is why microbiological research at the beginning of management administration of antimicrobials in these patients is of great importance.

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Published
2020-05-18
How to Cite
Nahaichuk, V. I., Nazarchuk, O. A., Babina, Y. M., Osadchuk, N. I., Bobyr, V. V., Dmytriiev, D. V., Palii, D. V., Makats, Y. F., & Chornopyshchuk, R. M. (2020). Analytic prognostication of sensitivity to fluoroquinolones in S. aureus, as pathogens of infectious complications in burn patients. Reports of Vinnytsia National Medical University, 24(1), 25-30. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2020-24(1)-05