Study of the effectiveness of using decamethoxin-based antiseptic compositions for treating endotracheal tubes in order to prevent the development of ventilator-associated pneumonia in intensive care patients


Keywords: ventilator-associated pneumonia, endotracheal intubation tubes, antiseptic coating.

Abstract

Annotation. The use of artificial lung ventilation in patients of intensive care unit often leads to airway contamination of conditionally pathogenic microorganisms and the development of ventilator-associated pneumonia. The clinical manifestations of ventilator-associated pneumonia can vary widely from mild to development of critical conditions accompanied by septic shock. This significantly worsens the patient's condition and prognosis for effective treatment. The paper presents the results of the study of the use of adhesive antiseptic compositions based on the domestic antiseptic drug decamethoxin in order to give antimicrobial properties to intubation tubes. An antibacterial adhesive was applied to the surface of segments of the endotracheal intubation tube, after which the samples were dried in a sterile box. The sensitivity of the microorganisms to the components of the antiseptic compositions was studied by the diameter of the growth retardation zone around the studied fragments of endotracheal intubation tubes placed in the thickness of the pre-seeded microorganism’s dense nutrient medium. The results were statistically analyzed using standard application package for biomedical research “STATISTICA 5.5”. It has been proved that adhesive film-forming compositions based on decamethoxin confer pronounced antimicrobial properties to endotracheal intubation tubes. The most susceptible to antimicrobial activity were gram-positive microorganisms of the genus Staphylococcus, and the most resistant were representatives of gram-negative bacteria of the genus Acinetobacter. The obtained research results allow us to predict the effectiveness of the use of adhesive hydrophilic and hydrophobic antiseptic compositions based on the domestic antiseptic decamethoxin to provide protective properties of the surface of endotracheal tubes, prevent the process of bacterial film formation and prevention of ventilator-associated patients.

References

1. Beloborodov, V. B. (2012). Problemy antibakterialnoj terapii tyazhelyh infekcij na primere nozokomialnoj pnevmonii, svyazannoj s provedeniem iskusstvennoj ventilyacii legkih i sepsisa [Problems of antibacterial therapy of severe infections by the example of nosocomial pneumonia associated with the implementation of artificial ventilation and sepsis]. Bolezni dyhatelnyh putej ̶ Diseases of the respiratory tract, 6, 289–293.

2. Sidashenko, O. I., Voronkova, O. S., & Sirokvasha, O. A. (2013). Bioplivka yak osoblyva forma orhanizatsii bakterii ta yii rol v infektsiinykh protsesakh [Biofilm as a special form of bacteria and its role in infectious processes]. Visnyk problem biolohii ta medytsyny – Bulletin of problems of biology and medicine, 2 (103), 36–40.

3. Trofimenko, Yu. Yu. (2015). Biolohichni vlastyvosti mikroflory, shcho kolonizuie endotrakhealni intubatsiini trubky u viddilenniakh intensyvnoi terapii [Biological properties of microflora colonizing endotracheal intubation tubes in intensive care units]. (Dys. kand. med. nauk). Vinnytskyi natsionalnyi medychnyi universytet im. M.I. Pyrohova, Vinnytsia.

4. Chekman, I. S., Horchakova, N. O., Okhotnikova, O. M., & Yakovleva, N. Iu. (2010). Nanotekhnolohii v pediatrychnii praktytsi: stan, perspektyvy doslidzhen [Nanotechnology in pediatric practice: status, prospects for research]. Ukrainskyi medychnyi chasopys – Ukrainian Medical Journal, 6 (80), 47–50.

5. Koenig, S. M., & Truwit, J. D. (2006). Ventilator-Associated Pneumonia: Diagnosis, Treatment, and Prevention. Clin. Microbiol. Rev., 19 (4), 637–657. DOI: 10.1128/CMR.00051-05.
Published
2020-05-18
How to Cite
Trofimenko, Y. Y., Zhorniak, O. I., Fomina, N. S., Burkot, V. M., Kulik, A. V., & Zhorniak, P. V. (2020). Study of the effectiveness of using decamethoxin-based antiseptic compositions for treating endotracheal tubes in order to prevent the development of ventilator-associated pneumonia in intensive care patients. Reports of Vinnytsia National Medical University, 24(1), 17-19. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2020-24(1)-03