Influence of environmental factors on the qualitative and quantitative parameters of male ejaculate (literature review)


  • S.V. Khmil Ternopil State Medical University
  • O.Yu. Mayorova Ternopil State Medical University
  • I.V. Dudchuk Professor S. Khmil's Medical Center
Keywords: ejaculate, spermogram, environmental factors

Abstract

Today it is important to study the problem of male infertility, as well as to identify the factors of its occurrence. The purpose of the work is to evaluate the overall picture of the quality of ejaculate during the last 50 years and to determine the reasons for such changes. More than 40 literary sources were published for thorough analysis in the period 1984–2018 (the share of new references is 20%). There was a decrease in sperm concentration by 1.5% / year, total sperm count — 1.6% / year, total sperm motility — 0.4% / year, decrease in the percentage of progressive motility sperm by 5.5% / year and with normal morphology 2.2% / year. One of the main reasons for the deterioration of sperm quality is the impact of negative environmental factors — chemical and radioactive contamination, as well as electromagnetic radiation. Among the most toxic substances are the heavy metals, pesticides, bisphenol A, phthalates, polychlorinated biphenyls, dioxin and its derivatives. Thus, over the last 50 years there has been a decline in the qualitative and quantitative indices of ejaculate men worldwide. One of the reasons is the worsening environmental situation.

References

1. Гурженко, Ю. М., & Куценко, А. О. (2016). Особливості порушень сперматогенезу чоловіків із безпліддям залежно від застосованих методик допоміжних репродуктивних технологій. Сімейна медицина, 5 (67), 132–137. Взято з http://nbuv.gov.ua/UJRN/simmed_2016_5_29. Hurzhenko, Yu. M., & Kutsenko, A. O. (2016). Osoblyvosti porushen spermatohenezu cholovikiv iz bezpliddiam zalezhno vid zastosovanykh metodyk dopomizhnykh reproduktyvnykh tekhnolohii [Features of disorders of spermatogenesis of men with infertility, depending on the applied methods of assisted reproductive technologies]. Simeina medytsyna – Family Medicine, 5 (67), 132–137.

2. Agarwal, A., Deepinder, F., Sharma, R. K., Ranga, G., & Li, J. (2008). Effect of cell phone usage on semen analysis in men attending infertility clinic: an observational study. Fertility and Sterility, 89, 124–128. doi: 10.1016/j.fertnstert.2007.01.166.

3. Akinloye, O., Arowojolu, A. O., Shittu, O. B. & Anetor, J. I. (2006). Cadmium toxicity: A possible cause of male infertility in Nigeria. Reproductive Biology, 6, 17–30. Retrieved from https://www.researchgate.net/publication/230824698_Cadmium_toxicity_a_possible_cause_of_male_infertility

4. Auger, J., Kunstmann, J. M., Czyglik, F., & Jouannet, P. (1995). Decline in semen quality among fertile men in Paris during the past 20 years. The New England Journal of Medicine, 332, 281–282.

5. Axelsson, J., Rylander, L., Rignell-Hydbom, A., & Giwercman, A. (2011). No secular trend over the last decade in sperm counts among Swedish men from the general population. Human Reproduction, 26 (5), 1012–1016. doi:10.1093/humrep/der045.

6. Bartoov, B., Zabludovsky, N., Eltes, F., Smirnov, V. V., Grischenko, V. I., & Fischbein, A. (1997). Semen Quality of Workers Exposed to Ionizing Radiation in Decontamination Work after the Chernobyl Nuclear Reactor Accident. International Journal of Occupational and Environmental Health, 3 (3), 204–209.

7. Bayasgalan, G., Naranbat, D., & Radnaabazar, J. (2004). Male infertility: Risk factors in Mongolian men. Asian Journal of Andrology, 6, 305–311.

8. Benvold, E., Gottlieb, C., Bygdeman, M., & Eneroth, P. (1991). Depressed semen quality in Swedish men from barren couples: a study over three decades. Archives of Andrology, 26, 189–194.

9. Butt, F., & Akram, N. (2013). Semen analysis parameters: Experiences and insight into male infertility at a tertiary care hospital in Punjab. Journal Of Pakistan Medical Association, 63, 558–562.

10. Carlsen, E., Giwercman, A., Keiding, N., & Skakkebaek, N. E. (1992). Evidence for decreasing quality of semen during past 50 years. British Medical Journal, 305, 609–613. Retrieved from https://www.bmj.com/content/bmj/305/6854/609.full.pdf.

11. Choy, C. M. Y., Lam, C. W. K., & Cheung, L. T. F. (2002). Infertility, blood mercury concentrations and dietary seafood consumption: a case-control study. An International Journal of Obstetrics and Gynaecology, 109, 1121–1125.

12. Cooper, T. G., Noonan, E., Eckardstein, von S., Auger, J., Baker, H. W., Behre, H. M. … Vogelsong K. M. (2010). World Health Organization reference values for human semen characteristics. Hum Reproduction Update, 16, 231–245. doi: 10.1093/humupd/dmp048.

13. Desai, N., Sharma, R., Makker, K., Sabanegh, E., & Agarwal, A. (2009). Physiologic and pathologic levels of reactive oxygen species in neat semen of infertile men. Fertility and Sterility, 92, 1626–1631. doi: 10.1016/j.fertnstert.2008.08.109.

14. Dickman, M. D., Leung, C. K., & Leung, M. K. (1998). Hong Kong male subfertility links to mercury in human hair and fish. Science of the Total Environment, 214, 165–174.

15. Fatima, P., Debnath, B. C., Hossain, M. M., Rahman, D., Banu, J., Begum, S., & Rahman, M. (2010). Relationship of blood and semen lead level with semen parameter. Mymensingh Medical Journal, 19 (3), 405–414. Retrieved from https://www.researchgate.net/publication/45272194_Relationship_of_blood_and_semen_lead_level_with_semen_parameter.

16. Feki, N. C., Abid, N., Rebai, A., Sellami, A., Ayed, B. B., Guermazi, M., … Ammar, L. K. (2009). Semen quality decline among men in infertile relationships: Experience over 12 years in the South of Tunisia. Journal of Andrology, 30 (5), 541–547. Retrieved from https://onlinelibrary.wiley.com/doi/epdf/10.2164/jandrol.108.005959.

17. Fenichel, P., Chevalier, N., Brucker-Davis, F., & Bisphenol, A. (2013). An endocrine and metabolic disruptor. Annales d'endocrinologie, 74 (3), 211–220. Retrieved from https://www.sciencedirect.com/journal/annales-dendocrinologie/vol/74/issue/3.

18. Geoffroy-Siraudin, C., Loundou, A. D., Romain, F., Achard, V., Courbière, B., Perrard, M. H., … Guichaoua M. (2012). Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, France. Asian Journal of Andrology, 14, 584–590. Retrieved from http://www.asiaandro.com/artsmore.asp?id=116.

19. Hjollund, N. H., Bonde, J. P., Jensen, T. K., Henriksen T. B., Andersson, A-M., Kolstad, H. A, …, Olsen, J. (2000). Male-mediated spontaneous abortion among spouses of stainless steel welders. Scandinavian Journal of Work, Environment & Health, 26, 187–192. Retrieved from https://www.sjweh.fi/show_issue.php?issue_id=50.

20. Jørgensen, N., Joensen, U. N., Jensen, T. K., Jensen, M. B., Almstrup, K., Olesen, I. A., … Skakkebæk, N. E. (2012). Human semen quality in the new millennium: A prospective cross-sectional population-based study of 4867 men. BMJ Open, 2 (4), 1–13. doi:10.1136/bmjopen-2012-000990.

21. Jørgensen, N., Vierula, M., Jacobsen, R., Pukkala, E., Perheentupa, A., Virtanen, H. E., … Toppari J. (2011). Recent adverse trends in semen quality and testis cancer incidence among Finnish men. International Journal of Andrology, 34 (4 Pt 2), e37–48. doi:10.1111/j.1365-2605.2010.01133.x.

22. Kesari, K. K., Agarwal, A., & Henkel, R. (2018). Radiations and male fertility. Reproductive Biology and Endocrinology, 16 (1), 118. doi:10.1186/s12958-018-0431-1.

23. Kumar, D., Salian, S. R., Kalthur, G., Uppangala, S., Kumari, S., Challapalli, S., … Kumar S. A. (2013). Semen abnormalities, sperm DNA damage and global hypermethylation in health workers occupationally exposed to ionizing radiation. PLoS One, 8 (7), e69927. doi:10.1371/journal.pone.0069927.

24. Kumar, N., & Singh, K. A. (2015). Trends of male factor infertility, an important cause of infertility: A review of literature. Journal of Human Reproductive Sciences, 8 (4), 191–196. doi: 10.4103/0974-1208.170370.

25. Latini, G., Dipaola, L., Mantovani, A., & Picano, E. (2012). Reproductive effects of low-to-moderate medical radiation exposure. Current Medicinal Chemistry, 19 (36), 6171–6177. doi:10.2174/0929867311209066171.

26. Molina, R. I., Martini, A. C., Tissera, A., Olmedo, J., Senestrari, D., de Cuneo, M. F., Ruiz R. D. (2010). Semen quality and aging: Analysis of 9.168 samples in Cordoba. Argentina. Archivos españoles de urología, 63, 214–222. Retrieved from https://www.researchgate.net/publication/43355120_Semen_quality_and_aging_Analysis_of_9168_samples_in_Cordoba_Argentina.

27. Murature, D. A., Tang, S. Y., Steinhardt, G., & Dougherty, R. C. (1987). Phthalate esters and semen quality parameters. Biomedical & environmental mass spectrometry, 14, 473–477. doi:10.1002/bms.1200140815.

28. Oliva, A., Spira, A., & Multigner, L. (2001). Contribution of environmental factors to the risk of male infertility. Human Reproduction, 16, (8), 1768–1776. doi:10.1093/humrep/16.8.1768.

29. Osser, S., Liedholm, P., & Ranstam, J. (1984). Depressed semen quality: A study over two decades. Archives of Andrology, 12, 113–6.

30. Paris, L., Cordelli, E., Eleuteri, P., Grollino, M. G., Pasquali, E., Ranaldi, R., ... Pacchierotti, F. (2011). Kinetics of gamma-H2AX induction and removal in bone marrow and testicular cells of mice after X-ray irradiation. Mutagenesis, 26 (4), 563–572. doi:10.1093/mutage/ger017.

31. Park, S. (2016) Genetic Factors and Environmental Factors Affecting Male Infertility. International Research Journal of Advanced Engineering and Science, 1 (3), 115–118. Retrieved from https://www.irjaes.com/pdf/IRJAES-V1N3Y16/IRJAES-V1N3P118Y16.pdf.

32. Queiroz, E. K., & Waissmann, W. (2006). Occupational exposure and effects on the male reproductive system. Cadernos de Saúde Pública, 22 (3), 485–493. Retrieved from http://www.scielo.br/pdf/csp/v22n3/03.pdf.

33. Rube, C. E., Zhang, S., Miebach, N., Fricke, A., & Rűbe, C. (2011). Protecting the heritable genome: DNA damage response mechanisms in spermatogonial stem cells. DNA Repair, 10 (2), 159–168. doi: 10.1016/j. dnarep.2010.10.007.

34. Shamsi, M. B., Kumar, R., & Dada, R. (2008). Evaluation of nuclear DNA damage in human spermatozoa in menopting for assisted reproduction. Indian Journal Medical Research, 127, 115–123. Retrieved from http://www.ijmr.org.in/showBackIssue.asp?issn=0971-5916;year=2008;volume=127;issue=2;month=February.

35. Sharma, A. (2017). Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human. Annals of Clinical and Laboratory Research, 5 (3:188), 1–10. doi: 10.21767/2386-5180.1000188.

36. Sikka, S. C., & Wang, R. (2008). Endocrine disruptors and estrogenic effects on male reproductive axis. Asian Journal of Andrology, 10 (1), 134–145. doi: 10.1111/j.1745-7262.2008.00370.x.

37. Singh, V., & Pakhiddey, R. (2015). Current scenario on genetic basis of infertility- A review. Acta Medica International, 2, 149–154. doi:10.5530/ami.2015.4.7.

38. Tang, Q., Wu, W., Zhang, J., Fan, R., & Liu, M. (2018). Environmental Factors and Male Infertility. R. Meccariello (Eds.). Spermatozoa. Facts and Perspectives (pp. 159–171). doi:10.5772/intechopen.71553.

39. Waeleghem, K. V., Clercq, N. D., Vermeulen, L., Schoonjans, F., & Comhair, F. (1996). Deterioration of sperm quality in young healthy Belgian men. Human Reproduction, 11 (2), 325–329. doi:10.1093/HUMREP/11.2.325.

40. Zhou, D. D., Hao, J. L., Guo, K. M., Lu, C. W., & Liu, X. D. (2016). Sperm quality and DNA damage in men from Jilin Province, China, who are occupationally exposed to ionizing radiation. Genetics and Molecular Research, 15 (1): 1–7. doi: 10.4238/gmr.15018078.
Published
2019-09-02
How to Cite
Khmil, S., Mayorova, O., & Dudchuk, I. (2019). Influence of environmental factors on the qualitative and quantitative parameters of male ejaculate (literature review). Reports of Vinnytsia National Medical University, 23(3), 530-534. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2019-23(3)-32