Features of feverish reaction in children with herpes virus infection

Keywords: children, Epstein-Barr herpes virus infection, fever reaction


One of the most persistent and striking manifestations of herpes virus infections is fever. The feverish reaction is different and depends from the child's age and the effect on the child's body of pyrogenic substances. The main biological and pathogenetic feature of herpesviruses is the long-term presence in the body of the child pathogens, which are present in different tissues. This causes the polymorphism of clinical manifestations and the severity of certain infectious diseases. The aim of our work was the analysis of modern scientific data regarding herpes infection and the observation of children in whom the fever lasted three or more days. We examined 86 children aged 1–7 years with herpesvirus infection in whom fever was observed. Verification of the diagnosis and clarification of herpes virus infection was carried out within 1–3 days from the moment of hospitalization by determining the polymerase chain reaction, Ig M and G to herpes viruses of types 1, 2, cytomegalovirus, Epstein-Barr virus and type 6 and 7 herpes viruses in blood and smears-prints of tonsils. The degree of activity of the inflammatory process in hepatocytes was evaluated by the level of alanine aminotransferases (ALT). To determine the extent of damage to hepatocytes used the indirect method — the Ritz coefficient. We used absolute and relative statistics using Microsoft Excel on an IBM PC/AT computer to evaluate the study results. In our study, 55.8% of children had pyretic fever (temperature above 39°C).The duration of the febrile reaction in 52.32% of patients was acute from 6 to 7 days. In 88.37% of children of the first 3 years of life with herpesvirus infection, a febrile reaction was accompanied by a general intoxication syndrome and manifestations of emotional lability, increased irritability, tearfulness, sleep disturbance, negative reaction to examination, and rapid fatigue. A rash on skin and mucous membranes was observed in 27.9% of children and an increase in the size of liver was recorded in 79.05% of patients.


1. Samsyigina, G. A. (2016). Gerpesvirusnyie infektsii u detey [Herpes virus infections in children]. Pediatriya — Pediatrics, 2, 8–23.

2. Tirskaya, O. I., & Molokov, V. D. (2015). Gerpeticheskaya infektsiya v polosti rta: sovremennyiy vzglyad na problemu [Herpetic infection in the oral cavity: a modern view of the problem]. Vestnik Severo-Vostochnogo federalnogo universiteta im. M.K.Amosova – Bulletin of the North-Eastern Federal University named after M.K. Amosov, 12, 1, 135–139.

3. Tsaregorodtsev, A. D., Ruzhitskaya, E. A., & Kisteneva, L. B. (2017). Persistiruyuschie infektsii v pediatrii: sovremennyiy vzglyad na problemu [Persistent infections in pediatrics: a modern view of the problem]. Rossiyskiy vestnik perintologii i pediatri – Russian Bulletin of Perintology and Pediatrics, 62 (1), 5–9.

4. Yulish, E. I., & Yaroshenko, S. Ya. (2013). Persistiruyuschie gerpesvirusnyie infektsii i ih rol v zabolevaemosti detey iz gruppyi chasto i dlitelno boleyuschih [Persistent herpes virus infections and their role in the incidence of children from the group of often and long-term sick]. Zdorove rebenka – Health of the child, 7 (50), 59–63.

5. Yakushina, S. A., & Kisteneva, L. B. (2018). Vliyanie persistentsii virusa Epshteyna-Barr na razvitie immunooposredovannyih somaticheskih zabolevaniy [The effect of the persistence of the Epstein-Barr virus on the development of immune-mediated somatic diseases]. Rossiyskiy vestnik perinatologii i pediatrii – Russian Bulletin of Perinatology and Pediatrics, 63 (1), 22–27.
How to Cite
Bulat, L., Medrashevskaya, Y., Fik, L., & Gyluk, O. (2019). Features of feverish reaction in children with herpes virus infection. Reports of Vinnytsia National Medical University, 23(3), 368-371. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2019-23(3)-04