Structural and hemodynamic changes in the carotid arteries in young healthy individuals with concentric remodeling of the left ventricle and with normal heart geometry

  • B.V. Sheremta National Pirogov Memorial Medical University, Vinnytsya
  • N.Yu. Osovskaya National Pirogov Memorial Medical University, Vinnytsya
Keywords: structural and hemodynamic changes in the carotid vessels, concentric remodeling of the left ventricle, daily monitoring of blood pressure


Remodeling of the heart and blood vessels is a complex multifactorial process that determines the prognosis of a patient with different cardiovascular pathologies. The aim of this work is to study in a comparative aspect the features of the hemodynamics of the carotid arteries as marker vessels of the elastic type and the daily blood pressure profile in young healthy individuals with concentric remodeling of the left ventricle and with normal heart geometry. The study involved practically healthy individuals from 18 to 42, aged 25.3±0.6 years, 56 (73.7%) men and 20 (26.36%) women. All study participants were divided into two equal groups depending on the value of the relative wall thickness of the left ventricle (RTW) for 38 people: for RTW>0.42 (concentric remodeling of the left ventricle) and for RTW≤0.42 (normal geometry of the left ventricle). The following research methods were used: echocardiography, 24-hour blood pressure monitoring, duplex scanning of the neck vessels. Statistical analysis of the study results was calculated using the methods of variational statistics using the StatSoft complex “Statistica” v.12. Although the average daily values of blood pressure and the degree of its nightly decline in both groups did not differ significantly, the speed of the morning rise and the variability of systolic pressure were significantly higher in patients with concentric remodeling than without it. That is, even in the absence of symptoms of cardiovascular disease and a history of a rise in blood pressure, the hemodynamic factor of a fast morning increase in blood pressure can take part in the formation of changes in the geometry of the heart in practically healthy young people. Changes in the speed-time parameters of blood flow in the common carotid arteries in the absence of wall thickening (intima-media complex) and a parallel increase in the lumen of the internal jugular veins found in the study indicate structural and hemodynamic vascular remodeling associated with concentric remodeling of the left ventricle in young, practically healthy persons.


1. Adzeriho, I. E. (2010). Arterialnaya gipertenziya: uprugo-elasticheskie svojstva krupnyh arterialnyh sosudov i effektivnost antigipertenzivnoj terapii [Arterial hypertension: the elastic properties of large arterial vessels and the effectiveness of antihypertensive therapy]. Medicinskie novosti – Medical news, 10, 24–28.

2. Alypova, O. Ye. (2014). Arterialna hipertenziia v konteksti sudynnoho remodeliuvannia: vyrisheni ta nevyrisheni pytannia [Arterial hypertension in the context of vascular remodeling: resolved and unresolved issues]. Zaporozhskyi medytsynskyi zhurnal – Zaporozhye medical journal, 2 (83), 72–76.

3. Davidovich, I. M., Afonaskov, O. V., & Porotikova, E. V. (2011). Autoregulyaciya sosudistogo tonusa u muzhchin molodogo vozrasta s gipertonicheskoj boleznyu: vliyanie antigipertenzivnoj terapii [Autoregulation of vascular tone in young men with hypertension: the effect of antihypertensive therapy]. Kardiovaskulyarnaya terapiya i profilaktika – Cardiovascular Therapy and Prevention, 2, 35–41.

4. Lelyuk, V. G., Lelyuk, S. E. (1997). Osnovnye principy gemodinamiki i ultrazvukovogo issledovaniya sosudov. V Mitkov, V. V. (Red). Klinicheskoe rukovodstvo po ultrazvukovoj diagnostike [The basic principles of hemodynamics and ultrasound examination of blood vessels. In Mitkov, V.V. (Ed.). Clinical Guide to Ultrasound Diagnostics.]. Moskva: Vidar.

5. Lyamina, S. V., Lyamina, N. P., & Senchihin, V. N. (2009). Variabelnost arterialnogo davleniya i sosudistyj krovotok v molodom vozraste pri arterialnoj gipertonii [Variability of blood pressure and vascular blood flow at a young age with arterial hypertension]. Fundamentalnye issledovaniya – Basic research, 10, 16–20.

6. Sharandak, A. P., Kirichenko, L. L., & Dvoryanchikova, Zh. Yu. (2003). Porazhenie organov-mishenej pri arterialnoj gipertonii. Rol nasledstvennosti i sredy (bliznecovoe issledovanie) [Damage to target organs with arterial hypertension. The role of heredity and environment (twin study)]. Kardiologiya – Cardiology, 43 (5), 29–32.

7. Benetos, А., Adamopoulos, C., Bureau, J-M., Temmar, M., Labat, C., Bean, K., … Guize, L. (2002). Determinants of Accelerated Progression of Arterial Stiffness in Normotensive Subjects and in Treated Hypertensive Subjects Over a 6-Year Period. Circulation, 105 (10), 1202–120. DOI:10.1161/hc1002.105135.

8. Chirinos, J. A., Segers, P., De Buyzere, M. L., Kronmal, R. A., Raja, M. W., De Bacquer, D., ... Rietzschel, E. R. (2010). Left ventricular mass: allometric scaling, normative values, effect of obesity, and prognostic performance. Hypertension, 56 (1), 91–98. doi: 10.1161/HYPERTENSIONAHA.110.150250.

9. Gaasch, W. H., & Zile, M. R. (2011). Left Ventricular Structural Remodeling in Health and Disease. With Special Emphasis on Volume, Mass, and Geometry. JACC, 58 (17), 1733–1740. doi: 10.1016/j.jacc.2011.07.022.

10. Hata, K., Nakagawa, T., Mizuno, M., Yanagi, N., Kitamura, H., Hayashi, T., ... Ogami, A. (2012). Relationship between smoking and a new index of arterial stiffness, the cardio-ankle vascular index, in male workers: a crosssectional study. Tobacco Induced Diseases, 10 (1), 11–16. doi: 10.1186/1617-9625-10-11.

11. Hermida, R. C., Smolensky, M. H., Ayala, D. E., & Portaluppi, F. (2013). 2013 ambulatory blood pressure monitoring recommendations for the diagnosis of adult hypertension, assessment of cardiovascular and other hypertension-associated risk, and attainment of therapeutic goals. Chronobiol. Int., 30 (3), 355–410. doi: 10.3109/07420528.2013.750490.

12. Kaess, B. M., Rong, J., Larson, M. G., Hamburg, N. M., Vita, J. A., Levy, D., … Mitchell, G. F. (2012). Aortic Stiffness, Blood Pressure Progression, and Incident Hypertension. JAMA, 308 (9), 875–881. doi: 10.1001/2012.jama.10503.

13. Kubozono, T., Miyata, M., Ueyama, K., Hamasaki, S., Kusano, K., Kubozono, O., & Tei, C. (2011). Acute and Chronic Effects of Smoking on Arterial Stiffness. Circ. J., 75 (3), 698–70. DOI: 10.1253/circj.cj-10-0552.

14. Payne, R. A., Wilkinson, I. B., & Webb, D. J. (2010). Arterial Stiffness and Hypertension: Emerging Concepts. Hypertension, 55 (1), 9–14. doi: 10.1161/HYPERTENSIONAHA.107.090464.
How to Cite
Sheremta, B., & Osovskaya, N. (2019). Structural and hemodynamic changes in the carotid arteries in young healthy individuals with concentric remodeling of the left ventricle and with normal heart geometry. Reports of Vinnytsia National Medical University, 23(3), 354-359.