Changes in the ducts of the pancreas with pancreatic necrosis


  • G.Ya. Kostyuk National Pirogov Memorial Medical University, Vinnytsya
  • O.G. Kostyuk National Pirogov Memorial Medical University, Vinnytsya
  • M.V. Burkov National Pirogov Memorial Medical University, Vinnytsya
  • I.A. Golubovsky National Pirogov Memorial Medical University, Vinnytsya
  • M.P. Bulko National Pirogov Memorial Medical University, Vinnytsya
  • L.O. Bandura National Pirogov Memorial Medical University, Vinnytsya
  • L.P. Magdebura Podil Regional Oncology Center
Keywords: pancreatic necrosis, morphological changes

Abstract

The article presents data on the development in the lumen of the pancreatic duct of condensed protein masses in people who died from the development of severe acute pancreatitis. 10 pancreas (areas of the head, body and tail, ductal system of the pancreas) of people who died of acute pancreatitis were subjected to histological examination. The material was fixed in 10% formalin solution, carried out in alcohols of increasing strength and enclosed in celloidin. The sections were stained with hematoxylin and eosin. A histological examination revealed that the condensed masses were represented by heterogeneous protein formations, cells of desquamated ductal epithelium, blood elements, fibrin threads. They completely filled the lumen of the pancreatic ducts and stopped the movement of pancreatic secretion. The data on the treatment of severe pancreatitis in experimental studies using the method of bougie and washing the pancreatic ducts with a novocaine-contrical mixture are presented. Two methods are proposed for restoring the permeability of the pancreatic duct in pancreatic necrosis in humans. Possible ways of the formation of fistulas and cysts are suggested, as a complication in the severe course of acute pancreatitis.

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Published
2019-09-02
How to Cite
Kostyuk, G., Kostyuk, O., Burkov, M., Golubovsky, I., Bulko, M., Bandura, L., & Magdebura, L. (2019). Changes in the ducts of the pancreas with pancreatic necrosis. Reports of Vinnytsia National Medical University, 23(3), 349-353. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2019-23(3)-01