Modern views on etiopathogenesis of traumatic injuries of the lower jaw against the background of osteoporosis and the use of drugs for correction of the processes of reparative osteogenesis


  • О. О. Lykhytskyi National Pirogov Memorial Medical University, Vinnytsya, Ukraine
Keywords: reparative osteogenesis, damage to the lower jaw, osteoporosis, etiology and pathogenesis

Abstract

 The purpose of the work is to analyze contemporary views on the etiopathogenesis of traumatic injuries of the lower jaw against the background of osteoporosis and the use of drugs to correct the processes of reparative osteogenesis. The analysis is based on a review of domestic and foreign articles and studies for 2006–2018, using the scientometric databases PubMed, eLIBRARY.RU, Web of Science. Damage to the lower jaw, namely its fractures, is a fairly common pathology both in Ukraine and in other countries of the world, and is associated with a violation of many key functions, in particular, nutrition and communication, and in case of complications, even a violation of aesthetic function. One of the factors that increase the likelihood of fracture formation is osteoporosis, a systemic disease of bone tissue characterized by a decrease in bone mass per unit volume and a violation of its microarchitecture. And if the problem of fractures of the lower jaw is sufficiently disclosed, then the features of the formation of fractures of this bone against the background of diseases, including against the background of osteoporosis, are not adequately addressed in both Ukrainian and foreign sources. This article presents modern works on the etiology and pathogenesis of traumatic injuries of the lower jaw against the background of osteoporosis and modern methods of correction of reparative osteogenesis.

Author Biography

О. О. Lykhytskyi, National Pirogov Memorial Medical University, Vinnytsya, Ukraine

assistant of the course of the basics of dentistry of the Department of Surgery №2 National Pirogov Memorial Medical University, Vinnytsya

References

1. Afanas'ev, V. V. (2010). Travmatologija cheljustno-licevoj oblasti [Maxillofacial traumatology]. M.: Izd. “GJeOTAR – Media”.

2. Barsukova, K. V., & Gorshkova, O. M. (2013). Gistohimicheskaja ocenka processa regeneracii kostnoj tkani pri ispol'zovanii preparata “Tizol'” [Histochemical evaluation of bone tissue regeneration using the “Tizol” drug]. Zhurnal anatomii i gistopatologii – Journal of Anatomy and Histopathology, 2 (3), 58–60.

3. Berezka, N. I., Litovchenko, V. A., Ivanov, A. N., & Garjachij, E. V. (2011). Optimizacija reparativnogo osteogeneza pri disregeneracii kostnoj tkani [Optimization of reparative osteogenesis in bone dysregulation]. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Serija: Medicina. Farmacija – Scientific reports of Belgorod State University. Series: Medicine. Pharmacy, 20 (141), 46–50.

4. Bragina, V. G., & Gorbatova, L. N. (2014). Travma cheljustno–licevoj oblasti u detej [Maxillofacial injury in children]. Jekologija cheloveka – Human ecology, 2, 20–24.

5. Vares, Ya. E., Filipskyi, A. V., & Filipska, T. A. (2011). Travmatohenez i struktura perelomiv nyzhnoi shchelepy [Traumatogenesis and structure of mandibular fractures]. Praktychna medytsyna – Practical medicine, 17 (5), 9–14.

6. Guljuk, A. G., & Zhelnin, E. V. (2013). Vzaimosvjaz' markerov osteogeneza i processov posttravmaticheskoj regeneracii al'veoljarnoj kosti u krys [The relationship between osteogenesis markers and posttraumatic regeneration processes in rat alveolar bone]. Fundamental'nye issledovanija – Basic research, 7, 534–539.

7. Guljuk, A. G., Tashhjan, A. Je., & Guljuk, L. N. (2012). Profilaktika oslozhnenij konsolidacii pri perelomah nizhnej cheljusti u bol'nyh so strukturno-metabolicheskimi izmenenijami kostnoj tkani [Prevention of complications of consolidation in fractures of the lower jaw in patients with structural and metabolic changes in bone tissue]. Visnyk stomatolohii – Bulletin of dentistry, 2, 65–71.

8. Deev, R. V., Bozo, I. Ja., Drobyshev, A. Ju., & Isaev, A. A. (2013). Jeffektivnost' gen-aktivirovannogo osteoplasticheskogo materiala s plazmidnymi DNK, soderzhashhimi gen VEGF, v zameshhenii kostnyh defektov [The effectiveness of gene-activated osteoplastic material with plasmid DNA containing the VEGF gene, in the replacement of bone defects]. Probl. kriobiologii i kriomediciny – Problems of cryobiology and cryomedicine, 23 (3), 355–358.

9. Zhelnin, E. V. (2012). Morfologicheskie osobennosti posttravmaticheskoj regeneracii al'veoljarnoj kosti v jeksperimente [Morphological features of post–traumatic regeneration of the alveolar bone in the experiment]. Ukrainskyi morfolohichnyi almanakh – Ukrainian morphological almanac, 10 (3), 35–38.

10. Zhelnin, E. V. (2013). Biohimicheskie kriterii prognozirovanija posttravmaticheskoj regeneracii al'veoljarnoj kosti v jeksperimente [Biochemical criteria for predicting post–traumatic regeneration of alveolar bone in an experiment]. Fundamental'nye issledovanija – Basic research, 9–6, 1006–1010.

11. Korzh, N. A., Deduh, N. V., & Nikol'chenko, O. A. (2006). Reparativnaja regeneracija kosti: sovremennyj vzgljad na problemu. Sistemnye faktory, vlijajushhie na zazhivlenie pereloma (soobshhenie 3) [Reparative bone regeneration: a modern view of the problem. Systemic factors affecting fracture healing (message 3)]. Ortopedija, travmatologija i protezirovanie – Orthopedics, traumatology and prosthetics, 2, 93–99.

12. Korotkih, N. G., Lesnikova, I. N., & Barsukova, K. V. (2013). Morfologicheskie kriterii regeneracii kosti nizhnej cheljusti u krolikov pri ispol'zovanii v terapii preparata “Tizol'” [Morphological criteria for lower jaw bone regeneration in rabbits when using the “Tizol” drug in therapy]. Vestnik novyh medicinskih tehnologij. Jelektronnoe izdanie – Bulletin of new medical technologies. Electronic edition, 1, 60.

13. Kotel'nikov, G. P., Kolsanov, A. V., Shherbovskih, A. E., Nikolaenko, A. N., Prihod'ko, S. A., Popov, N. V., & Hassan, M. A. (2017). Rekonstrukcija posttravmaticheskih i postoperacionnyh defektov nizhnej cheljusti [Reconstruction of post–traumatic and postoperative defects of the lower jaw]. Hirurgija – Surgery, 7, 69–72. DOI: 10.17116/hirurgia2017769–72.

14. Majborodin, I. V., Kolesnikov, I. S., Shevela, A. I., Sheplev, B. V., Drovosekov, M. N., & Toder, M. S. (2011). Vlijanie fibrinovogo sgustka pri povrezhdenii kosti nizhnej cheljusti v jeksperimente [The effect of a fibrin clot in case of damage to the lower jaw bone in the experiment]. Stomatologija – Stomatology, 4, 9–12.

15. Majborodin, I. V., Matveeva, V. A., Kolesnikov, I. S., Drovosekov, M. N., Toder, M. S., & Shevela, A. I. (2012). Vlijanie autologichnyh mezenhimal'nyh stvolovyh kletok kostnomozgovogo proishozhdenija na regeneraciju povrezhdennoj kosti nizhnej cheljusti krys [The effect of autologous mesenchymal stem cells of bone marrow origin on the regeneration of damaged bone of the lower jaw of rats]. Stomatologija – Stomatology, 1, 5–8.

16. Majborodin, I. V., Matveeva, V. A., Shevela, A. I., Sheplev, B. V., Kolesnikov, I. S., Vybornov, M. S., … & Shevela, A. A. (2010). Primenenie biodegradiruemyh poligidroksialkanoatov posle povrezhdenija kosti nizhnej cheljusti v jeksperimente [The use of biodegradable polyhydroxyalkanoates after damage to the lower jaw bone in the experiment]. Klinicheskaja stomatologija – Clinical Stomatology, 4, 54–57.

17. Oskol'skij, G. I., & Jurkevich, A. V. (2013). Cheljustno-licevaja ortopedija. Uchebnoe pocobie [Maxillofacial orthopedics. Tutorial]. Habarovsk: GBOU VPO DVGMU.

18. Saharov, A. V. (2011). Sravnitel'noe issledovanie reparativnoj regeneracii kostnoj tkani pri ispol'zovanii tkaneinzhenernoj matricy na osnove materiala “TIOPROST” i materiala “KOLLAPAN-M” [Comparative study of reparative regeneration of bone tissue using a tissue–engineering matrix based on the material “TIOPROST” and the material “KOLLAPAN-M”]. Geny i kletki – Genes and cells, 6 (4), 89–94.

19. Trifonov, B. V. (2013). Regeneracija kostnoj tkani pri zapolnenii ee defekta kompozitom “titanovoe volokno – kostnoplasticheskij material” [Bone tissue regeneration when filling its defect with a composite “titanium fiber – osteoplastic material”]. Kompozity i nanostruktury – Composites and Nanostructures, 2 (18), 59–64.

20. Fareniuk, O. O. (2014). Rozrobka metodyky indyvidualnoho pidboru varianta likuvannia patsiientiv iz perelomamy nyzhnoi shchelepy [Development of a method for individual selection of treatment options for patients with mandibular fractures]. Ukrainskyi stomatolohichnyi almanakh – Ukrainian dental almanac, 1, 51–62.

21. Chernichenko, A. A. (2008). Reparativnaja regeneracija kostnoj tkani nizhnej cheljusti pri ispol'zovanii titanovogo implantata v jeksperimente [Reparative regeneration of bone tissue of the lower jaw using a titanium implant in an experiment]. Sibirskoe medicinskoe obozrenie – Siberian Medical Review, 49 (1), 29–33.

22. Chernjaev, S. E., & Kiseleva, E. V. (2009). Vozmozhnosti ispol'zovanija stvolovyh kletok u detej s patologiej cheljustno-licevoj oblasti [Possibilities of using stem cells in children with maxillofacial pathology]. Tezisy predstavleny v materialah III Vserossijskoj nauchno-prakticheskoj konferencii “Vrozhdennaja i nasledstvennaja patologija golovy, lica i shei u detej: aktual'nye voprosy kompleksnogo lechenija”, Moskva (str. 190–192). M.: [b. i.].

23. Arosarena, O., Ducic, Y., & Tollefson, T. T. (2012). Mandible fractures: discussion and debate. Facial. Plast. Surg.Clin. North. Am., 20 (3), 347–363. DOI: https://doi.org/10.1016/j.fsc.2012.05.001.

24. Avenell, A., Mak, J. C., & O'Connell, D. (2014). Vitamin D and vitamin D analogues for preventing fractures in post–menopausal women and older men. Cochrane Database Syst. Rev., 14 (4), CD000227. https://doi.org/10.1002/14651858.CD000227.pub4.

25. Bauer, D. C. (2013). Clinical practice. Calcium supplements and fracture prevention. N. Engl. J. Med., 369, 1537–1543. DOI: 10.1056/NEJMcp1210380.

26. Caplan, A. I., & Correa, D. (2011). PDGF in bone formation and regeneration: New insights into a novel mechanism involving MSCs. J. Orthop. Res., 29, 1795–1803. https://doi.org/10.1002/jor.21462.

27. Claes, L., Recknagel, S., & Ignatius, A. (2012). Fracture healing under healthy and inflammatory conditions. Nat. Rev. Rheumatol., 8, 133–143. https://doi.org/10.1038/nrrheum.2012.1.

28. Dillon, J. K., Christensen, B., McDonald, T., Huang, S., Gauger, P., & Gomez, P. (2012). The financial burden of mandibular trauma. J. Oral. Maxillofac. Surg., 70 (9), 2124–2134. https://doi.org/10.1016/j.joms.2012.04.048.

29. Feng, J., Liu, S., Ma, S., Zhao, J., Zhang, W., Qi, W., … Lei, W. (2014). Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1–NF–κB signaling pathway. Acta Biochim Biophys Sin (Shanghai), 46 (12), 1024–1033. https://doi.org/10.1093/abbs/gmu103.

30. Garcia, P., Histing, T., Holstein, J. H., Klein, M., Laschke, M. W., Matthys, R., … Menger, M. D. (2013). Rodent animal models of delayed bone healing and non–union formation: A comprehensive review. European Cells and Materials, 26, 1–14.

31. Goldhahn, I., Little, D., Mitchell, P., Fazzalari, N. L., Reid, I. R., Aspenberg, P., & Marsh, D. (2010). Evidence for anti–osteoporosis therapy in acute fracture situations – recommendations of a multidisciplinary workshop of the International Society for Fracture Repaire. Bone, 46 (2), 267–271. https://doi.org/10.1016/j.bone.2009.10.004.

32. Govindarajan, P., Böcker, W., El Khassawna, T., Kampschulte, M., Schlewitz, G., Huerter, B., … Heiss, C. (2014). Bone matrix, cellularity, and structural changes in a rat model with high turnover osteoporosis induced by combined ovariectomy and a multiple–deficient diet. Am. J. Pathol., 184 (3), 765–777. https://doi.org/10.1016/j.ajpath.2013.11.011.

33. Han, N. R., Park, C. L., Kim, N. R., Kim, H. Y., Yoou, M. S., Nam, S. Y., … Kim, H. M. (2015). Protective effect of porcine placenta in a menopausal ovariectomized mouse. Reproduction, 150 (3), 173–181. DOI: 10.1530/REP–15–0157.

34. Hong, J. W., Lee, W. J., Hahn, S. B., Kim, B. J., & Lew, D. H. (2010). The effect of human placenta extract in a wound healing model. Ann. Plast. Surg., 65 (1), 96–100. DOI: 10.1097/SAP.0b013e3181b0bb67.

35. Ibrahim, N., Mohamad, S., Mohamed, N., & Shuid, A. N. (2013). Experimental fracture protocols in assessments of potential agents for osteoporotic fracture healing using rodent models. Curr. Drug. Targets, 14, 1642–1650.

36. Kanis, J. A., Cooper, C., Rizzoli, R., Abrahamsen, B., Al–Daghri, N. M., Brandi, M. L., … & Thomas, J.–Y. T. (2017). Identification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting. Osteoporos Int., 28 (7), 2023–2034. https://doi.org/10.1007/s00198–017–4009–0.

37. Li, Y., Tan, Y., Zhang, G., Yang, В., & Zhang, J. (2009). Effects of calcitonin Gene–Related Peptide on the expression and activity of Nitric Oxide Synthase during mandibular bone healing in rabbits: An Experimental study. J. Oral MaxIIIofac Surg., 67, 273–279. https://doi.org/10.1016/j.joms.2008.06.077.

38. Marini, F., Cianferotti, L., & Brandi, M. L. (2016). Epigenetic Mechanisms in Bone Biology and Osteoporosis: Can They Drive Therapeutic Choices? Int. J. Mol. Sci., 17 (8), 13–29. https://doi.org/10.3390/ijms17081329.

39. Naveen Shankar, A., Naveen Shankar, V., Hegde, N., & Sharma, P. R. (2012). The pattern of the maxillofacial fractures – A multicentre retrospective study. J. Craniomaxillofac Surg., 40 (8), 675–679. https://doi.org/10.1016/j.jcms.2011.11.004.

40. Robbins, J. A., Aragaki, A., Crandall, C. J., Manson, J. E., Carbone, L., Jackson, R., … & Wactawski-Wende, J. (2014). Women’s Health Initiative clinical trials: interaction of calcium and vitamin D with hormone therapy. Menopause, 21, 116–123. https://doi.org/10.18370/2309–4117.2015.26.94–101.

41. Roux, C., Bischoff-Ferrari, H. A., Papapoulos, S. E., de Papp, A. E., West, J. A., & Bouillon, R. (2008). New insights into the role of vitamin D and calcium in osteoporosis management: an expert roundtable discussion. Curr. Med. Res. Opin., 24 (5), 1363–1370. https://doi.org/10.1185/030079908X301857.

42. Taylor, C. L., Sempos, C. T., Davis, C. D., & Brannon, P. M. (2017). Vitamin D: Moving Forward to Address Emerging Science. Nutrients, 9 (12), 130–138. https://doi.org/10.3390/nu9121308.

43. Tu, K. N., Lie, J. D., Wan, C. K. V., Cameron, M., Austel, A. G., Nguyen, J. K., … Hyun, D. (2018). Osteoporosis: A Review of Treatment Options. PMC, 43 (2), 92–104.

44. Zhao, J. G., Zeng, X. T., Wang, J., & Liu, L. (2017). Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis. JAMA, 318 (24), 2466–2482. DOI:10.1001/jama.2017.19344.

45. Zhou, H. H., Liu, Q., Cheng, G., & Li, Z. B. (2013). Aetiology, pattern and treatment of mandibular condylar fractures in 549 patients: a 22-year retrospective study. J. Craniomaxillofac. Surg., 41 (1), 34–41. https://doi.org/10.1016/j.jcms.2012.05.007.
Published
2019-06-27
How to Cite
LykhytskyiО. О. (2019). Modern views on etiopathogenesis of traumatic injuries of the lower jaw against the background of osteoporosis and the use of drugs for correction of the processes of reparative osteogenesis. Reports of Vinnytsia National Medical University, 23(2), 309-315. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2019-23(2)-24