Clinical and laboratory features of viral hepatitis B among HIV-patients in Zambia


  • L. V. Moroz National Pirogov Memorial Medical University, Vinnytsya, Ukraine https://orcid.org/0000-0002-7111-3155
  • S. Ch. Soni National Pirogov Memorial Medical University, Vinnytsya, Ukraine https://orcid.org/0000-0002-7478-507X
  • K. D. Chichirelo-Konstantynovych National Pirogov Memorial Medical University, Vinnytsya, Ukraine https://orcid.org/0000-0002-7403-636X
  • S. M. Kulias National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • O. O. Popovych National Pirogov Memorial Medical University, Vinnytsya, Ukraine
Keywords: viral hepatitis B, HIV-infection, Zambia, clinical features, laboratory features, course

Abstract

Viral hepatitis B course in HIV patients in Zambia is still bad studied. At present, the study of the influence of immunosuppression on the clinical and laboratory features of viral hepatitis B acquires a special relevance. The aim of research is to investigate clinical and laboratory features of viral hepatitis B course among HIV-patients in Zambia. Epidemiological, descriptive, serological (HBV, HIV markers), biochemical (cytolysis and cholestasis syndromes’ indicators), statistic method for determining the reliability using average errors (m), t-criterion of the probability difference of the Student) methods are used. The results show HBV/HIV-positive Zambian patients reliably differ from HBV-monoinfected ones. As well, HBV/HIV-positive patients have significantly higher indexes of asteno-vegetatic, dyspeptic syndromes, hepato- and splenomegaly, cytolysis indexes (alanine aminotransferase, lactate dehydrogenase), which are associated with increase of HIV-infection’s stage. Hepatocellular deficiency’s indicators don’t differ reliably in comparison groups. Therefore, HBV/HIV-infected patients have more severe clinical and laboratory course than HBV-monoinfected ones.

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Published
2019-06-27
How to Cite
Moroz, L. V., Soni, S. C., Chichirelo-Konstantynovych, K. D., Kulias, S. M., & Popovych, O. O. (2019). Clinical and laboratory features of viral hepatitis B among HIV-patients in Zambia. Reports of Vinnytsia National Medical University, 23(2), 257-262. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2019-23(2)-14