Study of the dynamics of anticonvulsant and anxiolytic action after oral administration of tin (II) chloride


Keywords: tin chloride, anticonvulsant activity, anxiolytic, sedative effect, depressive disorders

Abstract

This article is devoted to the study of anticonvulsant and anxiolytic activity of tin (II) chloride by oral administration. The anxiolytic effect was established in models of the Open Field and Black-and-White Camera tests; the anticonvulsant activity of SnCl (II) was evaluated in model of acute generalized seizures with the determination of pentylenetetrazole (PTZ) minimum effective doses inducing clonic-tonic convulsions and tonic extension in test animals. Statistical indicators were calculated using the Microsoft Excel software package using the arithmetic mean value (M) and the mean deviation mean value (m). The obtained data show that tin (II) chloride is a promising compound for the prevention of anxiety states, as well as disorders containing the convulsive component. Three hours after the start of the experiment, the minimum doses of pentylenetetrazole for inducing clonic-tonic convulsions and tonic extension, exceeded the control group data by an average of 75%. A decrease in motor activity by half compared with the control in the open field test during the 5 hours of the experiment indicates the sedative effect of tin (II) chloride. Tin (II) chloride is a promising compound for the relief of convulsive states and correction of depressive disorders. Thus, it is of interest to further study the spectrum of its pharmacological activity in order the use it in medicine.

Author Biographies

О. G. Prokopchuk, Odessa National Polytechnic University, Odessa, Ukraine

Odessa National Polytechnic University, senior lecturer

O. I. Aleksandrova, Odessa National Polytechnic University, Odessa, Ukraine

Odessa National Polytechnic University, PhD, Associate Professor

I. A. Kravchenko, Odessa National Polytechnic University, Odessa, Ukraine

Odessa National Polytechnic University, doctor of biological sciences, professor, head of the department

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Published
2019-06-27
How to Cite
ProkopchukО. G., Aleksandrova, O. I., & Kravchenko, I. A. (2019). Study of the dynamics of anticonvulsant and anxiolytic action after oral administration of tin (II) chloride. Reports of Vinnytsia National Medical University, 23(2), 204-208. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2019-23(2)-03