Clinical, epidemiological and laboratory features of acute brucellosis in the Republic of Azerbaijan

Keywords: acute brucellosis, transmission pathway, hepatosplenomegaly, sacroiliitis.


Brucellosis is one of the most common zoonotic infections in the world with a high percentage of chronic forms, which respectively negatively affects the economic component of health systems in countries with high prevalence of brucellosis. The purpose of our study was to determine the clinical, epidemiological and laboratory features of acute brucellosis in the Republic of Azerbaijan. We were screened 178 patients with acute brucellosis who applied for medical services at the Baku Clinic and the Central Clinical Hospital in Baku. Specific methods of the study were conducted by ELISA with the detection of IgM and IgG. Statistical processing the results of the study was performed using the programs “SPSS 20.0”, “STATISTICA 6.0”. Among brucellosis patients, men (75.00%) of the young age (65.00%) who live in rural areas prevail. It was found that in 7.5 times more acute brucellosis was observed among women aged 40–49 years (p<0.05), whereas in the group under 19 years of age, brucellosis was not detected in women. The dominant ways of infection were: contact — in 45.00% of patients with acute brucellosis and alimentary — in 32.5% of people. Among the study group of patients with acute brucellosis, the most frequent clinical symptoms that attracted attention were fever — 86.67%, general weakness — 87.50%), sweating — 70.00%, and arthralgia — 64.17%. While the least of all patients indicated myalgia and body weight loss — 25.83% of individuals. We found that sacroiliitis and peripheral arthritis were 15.8 and 12 times more likely to occur in women than men (p<0.05). The main changes in the general analysis of blood and biochemical analysis are anemia (53.33%), elevated ESR (72.50%), elevation of ALT and AST (35.83% and 40.00% respectively).

Author Biography

Yelchin Mamed oglu Huseynov, Azerbaijan Medical University

Elchin Huseynov Mammad oglu - PhD, docent, Department of Infectious Diseases Azerbaijan Medical University, mob. tel. +994502122813, Ідентифікатор ORCID


1. Bukharie, H. A. (2009). Clinical features, complications and treatment outcome of Brucella infection: Ten years' experience in an endemic area. Tropical Journal of Pharmaceutical Research, 8 (4).

2. Cemal Bulut, Meltem Arzu Yetkin, Gülruhsar Yilmaz, Fatma Şebnem Erdinç, Çiğdem Ataman Hatipoğlu, Sami Kinikli … Ali Pekcan Demiröz. (2011). Assessment of the findings on the existence of complications in brucellosis. Turkish Journal of Medical Sciences, 41 (2), 275–282. doi:10.3906/sag-0908-17.

3. Buzgan, T., Karahocagil, M. K., Irmak, H., Baran, A. I., Karsen, H., Evirgen, O. & Akdeniz, H. (2010). Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. International journal of infectious diseases, 14 (6), e469-e478. DOI:

4. Garcell H. G., Garcia, E. G., Pueyo, P. V., Martín, I. R., Arias, A. V. & Serrano, R. N. A. (2016). Outbreaks of brucellosis related to the consumption of unpasteurized camel milk. Journal of infection and public health, 9 (4), 523–527.

5. Kazak, E., Akalın, H., Yılmaz, E., Heper, Y., Mıstık, R., Sınırtaş, M. … Helvacı, S. (2016). Brucellosis: a retrospective evaluation of 164 cases. Singapore medical journal, 57 (11), 624. doi: 10.11622/smedj.2015163.

6. Mugahi, S., Nashibi, R., Alavi, S. M., Gharkholu, S. & Najafi, K. (2014). Epidemiological features, clinical manifestation and laboratory findings of patients with brucellosis. Archives of Clinical Infectious Diseases, 9 (1). DOI: 10.5812/archcid.17270.

7. Najafi, N., Davoudi, A., Hassantabar S. R. & Haddadi, R. (2018). Investigating the Epidemiologic, Laboratory, and Clinical Features of Brucellosis Patients Hospitalized in the North of Iran During 2009-2014. Archives of Clinical Infectious Diseases, 13 (2), e61012. doi: 10.5812/archcid.61012.

8. Nassaji, M., Govhary, A. & Ghorbani, R. (2015). Epidemiological, clinical and laboratory findings in adult patients with acute brucellosis: A case-control study. Acta Medica Mediterranea, 31, 1319–1325.

9. Nourbakhsh, F., Borooni, S., Barangi, S. & Tajbakhsh, E. (2017). Diagnosis of clinical and laboratory findings of brucellosis in Isfahan. International Archives of Health Sciences, 4 (2), 48. DOI: 10.4103/iahs.iahs_1_17.

10. Rahil, A. I., Walid, M. O., Yahya Mohamed, I. M. (2014). Brucellosis in Qatar: a retrospective cohort study. Qatar medical journal, 4.

11. Savas, L., Onlen, Y., Savas, N., Yapar, A., Aydin, M. & Tugal, O. (2007). Prospective evaluation of 140 patients with brucellosis in the southern region of Turkey. Infectious Diseases in Clinical Practice, 15 (2), 83–88. doi: 10.1097/01.idc.0000240863.82188.95.

12. Sofian, M., Aghakhani, A., Velayati, A. A., Banifazl, M., Eslamifar, A. & Ramezani, A. (2008). Risk factors for human brucellosis in Iran: a case-control study. International journal of infectious diseases, 12 (2), 157–161.

13. Turan, H., Serefhanoglu, K., Karadeli, E., Togan, T. & Arslan, H. (2011). Osteoarticular involvement among 202 brucellosis cases identified in Central Anatolia region of Turkey. Internal Medicine, 50 (5), 421–428.
How to Cite
Huseynov, Y. M. oglu. (2019). Clinical, epidemiological and laboratory features of acute brucellosis in the Republic of Azerbaijan. Reports of Vinnytsia National Medical University, 23(1), 167-171.