The role of estrogen and progesterone receptors in women with adenomyosis in postmenopause


  • G.Y. Honcharenko
Keywords: adenomyosis, postmenopause, estrogen and progesterone receptors.

Abstract

Adenomyosis (AD) is an urgent medical problem of the present. The issues of etiology and pathogenesis of internal endometriosis remain controversial. The purpose of the work is to define the role of estrogen (ER) and progesterone (PR) receptors in the pathogenesis of adenomyosis (AD) in postmenopausal women. Selection criteria: established diagnosis of AD, postmenopausal period (no menstruation for more than 1 year) and absence of concomitant endometrial pathology. An immunohistochemical (IHС) study was performed to determine the state of the receptor apparatus for markers of estrogen and progesterone. The IНC study of the eu- and ectopic endometrium receptor apparatus revealed the presence of ER and RR expression both in epithelial cells and stromal cells, indicating the hormonal dependence of AD foci and the key role of steroid hormones in the development and preservation of intraocular endometriosis in postmenopausal women. Nearly a third of women in the epithelial cells of the eutopic endometrium found a normal correlation between ER and PR, respectively leading to 1. In stromal cells, a decrease in ER was observed with an increase in RR (ER / PR <1) in 9 out of 15 patients. Analysis of the distribution of the ratio of expression ratios of ER and PR in ectopic endometrium revealed the predominance of the role of PR in ER in the pathogenesis of internal endometriosis. The components of the ectopic endometrium in most women were characterized by an increase in PR and a decrease in ER (ER / PR <1).

Author Biography

G.Y. Honcharenko

Honcharenko G. Y., part-time post-graduate department of pathological anatomy with sectional course, Odesa National Medical University, Ukraine. +380974088359. E-mail: 270916gr@gmail.com. http://orcid.org/0000-0003-3399-2910

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Published
2019-03-01
How to Cite
Honcharenko, G. (2019). The role of estrogen and progesterone receptors in women with adenomyosis in postmenopause. Reports of Vinnytsia National Medical University, 23(1), 148-152. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2019-23(1)-26