Influence of some comorbid and polymorbid states on the indicators of hemostasis in patients with ischemic heart disease and percutaneous angioplasty


Keywords: ischemic heart disease, percutaneous coronary angioplasty, restenosis, comorbid conditions, hemostasis.

Abstract

Identification of markers of possible thrombotic complications in patients with ischemic heart disease and percutaneous angioplasty with comorbid conditions on the background is significant for preventive medical interventions, depending on the degree of thrombotic risk. The hemostasis markers (sF, fibrinogen, D-dimer and C-protein) of 91 patients (77 men and 14 women) with ischemic heart disease and percutaneous angioplasty, of whom 32 patients had a stent retrombosis in anamnesis, were measured in different groups of comorbidity and polymorbidity. The purpose of the paper is to investigate changes in hemostasis in some comorbid conditions in patients with ischemic heart disease and percutaneous angioplasty, as well as to identify possible markers of thrombinemia. The results of the study suggest that the presence of comorbidity and polymorbidity in the investigated patients acts as a prognostic weighting factor in the development of thrombotic complications. A comprehensive study of hemostasis markers, among which sF is the most informative one, objectively characterizes disorders in the hemostasis system, while diabetes mellitus and restenosis in the anamnesis being the most dangerous comorbid conditions during the development of thrombotic complications.

Author Biographies

N.V. Storozhuk

Сторожук Надія Василівна – асистент кафедри кафедри внутрішньої медицини №3Вінницького національного медичного університету ім. М.І. Пирогова, shevchuk.nadyush@gmail.com  Тел. +38(098)812-5288; ORCID 0000-0003-4424-4990.

T.M. Platonova

Платонова Тетяна Миколаївна – д.б.н., співробітник відділу біології білку Інституту біохімії ім. О.В.Палладіна, platonovatn@gmail.com Тел. +38(050)569-2388; ORCID 0000-0002-7241-1146.

B.G. Storozhuk

Сторожук Борис Григорович – д.мед.н., професор кафедри внутрішньої медицини №3 Вінницького національного медичного університету ім. М.І. Пирогова, storozhuk0323@gmail.com  Тел. +38(050)313-3302; ORCID 000-0002-9590-2159.

E.V. Lugovskoy

Луговськой Едуард Віталійович – професор, чл-кор. АН України, зав. відділом біології білку Інституту біохімії ім. О.В.Палладіна, lougovskoy@yahoo.com  Тел. (044)234-2335; ORCID 0000-0002-8958-7463.

L.A. Storozhuk

Сторожук Лариса Олександрівна – к.мед.н., ст.н.с., провідний науковий співробітник НДІ реабілітації інвалідів Вінницького національного медичного університету ім. М.І. Пирогова, larinastorozhuk@gmail.com  Тел. +38(095)208-9869; ORCID 0000-0002-4591-9534.

T.V. Dovgalyuk

Довгалюк Тетяна Вікторівна – вчений секретар НДІ реабілітації інвалідів Вінницького національного медичного університету ім. М.І. Пирогова, postboxt05@gmail.com  Тел. +38(050)063-6522; ORCID 0000-0003-1614-9021.

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Published
2019-03-01
How to Cite
Storozhuk, N., Platonova, T., Storozhuk, B., Lugovskoy, E., Storozhuk, L., & Dovgalyuk, T. (2019). Influence of some comorbid and polymorbid states on the indicators of hemostasis in patients with ischemic heart disease and percutaneous angioplasty. Reports of Vinnytsia National Medical University, 23(1), 134-137. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2019-23(1)-23