Dynamics of changes in the immune system and antioxidant protection in the treatment of acute pancreatitis


  • K. E. Ishcheikin
  • V. V. Petrushenko
  • D. I. Grebeniuk
  • O. M. Zatserkovna
  • L. M. Malyk
  • N.F. Liakhovchenko
Keywords: acute pancreatitis, immune system, antioxidant protection, antibiotic therapy, fluoroquinolones.

Abstract

The aim of the work was to study the dynamics of changes in the immune system indices and antioxidant protection when fluoroquinolones are included in the treatment regimen for acute edematous pancreatitis. The study included 86 patients with a diagnosis of acute edematous pancreatitis. Group I (n=40) consisted of patients who received treatment according to national and local standards and protocols, group II (n=46) — patients who additionally received fluoroquinolones as part of a comprehensive treatment. The control group consisted of 48 conditionally healthy people in whom laboratory and instrumental diagnostics were carried out similarly to those in patients with acute pancreatitis. According to the purpose and objectives of the study, the state of the immune system and the antioxidant defense system was studied. In patients with acute pancreatitis, changes in the indicators of the immune status were revealed, manifested by the formation of a secondary immunodeficiency with the addition of an autoimmune component. The traditional scheme of pharmacotherapy of acute pancreatitis without the use of antibiotics made it possible to partially correct the indicators of immune status. The use of ciprofloxacin in the complex pharmacotherapy of acute pancreatitis contributed to the normalization of the studied parameters. Thus, the use of fluoroquinolones in the complex pharmacotherapy of acute pancreatitis made it possible to effectively normalize the state of the immune system, cytokine and antioxidant statuses.

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Published
2019-03-01
How to Cite
Ishcheikin, K. E., Petrushenko, V. V., Grebeniuk, D. I., Zatserkovna, O. M., Malyk, L. M., & Liakhovchenko, N. (2019). Dynamics of changes in the immune system and antioxidant protection in the treatment of acute pancreatitis. Reports of Vinnytsia National Medical University, 23(1), 110-113. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2019-23(1)-18