The morphological changes in parathyroid glands, caused simulated prolonged influence of heavy metal salts
The main problem today is environmental pollution with heavy metal salts. Biological activity and their ability to accumulate in the environment and the body leads to the disruption of many systems and organs. Parathyroid glands are important regulators of calcium homeostasis, which affects a lot of physiological processes in the body. Therefore, the work is devoted to the study of the morphological and functional characteristics of the parathyroid glands of laboratory rats under conditions of prolonged use of a combination of heavy metal salts. Study of the peculiarities of the structure and functional activity of the glands was carried out on adult male rats (n = 12). The animals were divided into groups: the first — its control, the second — rats, which received a water solution of a mixture of salts of heavy metals. The material was taken on the 90th day of the experiment. Histological preparations were made 5–7 microns thick, stained with hematoxylin and eosin. Study of the linear parameters of the parathyroid glands was carried out on the largest longitudinal section. The area of the glands and cells, the thickness of the capsule and the layer of connective tissue in the parenchyma of the organ were measured. During the laboratory study of the blood of rats, the content of calcium and magnesium was determined, as well as the activity of parathyroid hormone. Conducted statistical treatment of the data. It has been established that with long-term admission of a combination of salts of heavy metals into the organism of rats leads to morphological changes in the parenchyma and stroma of the glands, there are changes in the content of calcium and magnesium in the biochemical parameters of blood, as well as inhibition of parathormone secretion. In the future, it is planned to study the morphofunctional features of the parathyroid glands in the process of readoptation after consuming a combination of heavy metal salts.
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