Galactin-3 as biomarker of chronic heart failure in patients with essential hypertension of men


  • V.O. Ruzhanska
  • V.G. Sivak
  • V.М. Zhebel
  • Yu.P. Pashkova
Keywords: angiotensin II receptor polymorphism type II (AT1R), brain natriuretic peptide, galectin-3, arterial pressure.

Abstract

Summary. In work concentration of a biomarker galektina-3 at persons with the chronic heart failure (CHF) which arose against the background of the essential hypertension (EH) at a carriage of polymorphic genes of a receptor of an angiotensin ІІ type 1 (AT1R) and appropriate levels of a brain natriuretic peptide (BNP) at EG were studied. The control group consisted of 79 persons, the group with uncomplicated EG included 62 persons, in the group with CHF II, A stage II-III of FC for NYHA 50 persons, residents of Podillia region of Ukraine, aged 40-60 years. The genotyping of the AT1R gene was carried out using a polymerase chain reaction. BNP and galectin-3 plasma level were determined by ELISA. In practically healthy men, the inhabitants of the Podillia region dominate the genotype A1166A. At the same time, it was found that among the patients with EG and CHF, the carriers of the allele C predominate. Carriers of the allele C of the AT1R gene have a significantly higher level of BNP and galectin-3 compared to carriers of the genotype A1166A, which may be of a diagnostic value.

Published
2017-09-29
How to Cite
Ruzhanska, V., Sivak, V., Zhebel, V., & Pashkova, Y. (2017). Galactin-3 as biomarker of chronic heart failure in patients with essential hypertension of men. Reports of Vinnytsia National Medical University, 21(2), 563-569. Retrieved from https://reports-vnmedical.com.ua/index.php/journal/article/view/59