Results of 3-D reconstruction in dynamic analysis for determining the bone tissue density of the maxilla in human prenatal ontogenesis


Keywords: maxilla, computed tomography, density, bone tissue, prenatal ontogenesis, human.

Abstract

The quality of the bone tissue of the jaw bones is of special significance since it is characterized by the pronounced age dynamics and depends both on the course of the mineralization of the skeleton as a whole, and on the specifics of the mineral content of the bone tissue of the particular jaws. The aim is to find out the peculiarities of bone density (MO Hu) in various anatomical areas of the germs of the human maxillary jaw in the dynamics of prenatal ontogenesis using computed tomography and standardized software i-CATVision. The study has been conducted using macroscopy, morphometry, computed tomography, and statistical analysis. The study of the germs of the maxilla in prenatal ontogenesis confirms the asynchrony of density, which is directly proportional to its mineralization, between the right and left sides, which is most pronounced in the alveolar, malar and palatal ridges. Mineral saturation of bone tissue, which reflects its density (MO Hu), is an interdependent coefficient of ratio to its growth rate (%). Alveolar ridges maintain a stable, non-correlated dynamic growth sequence in all experimental age groups, in the frontal area, with a rate of density increase (%) up to 30 weeks of prenatal ontogenesis. The highest density factor of the malar ridges accounts for the 11–16 weeks of the development of the fetus, in the percentage distribution of mineral saturation among the frontal, palatal and alveolar ridges, more than a third of the total value. This analysis forms the idea of the distribution of micro and macro elements that provide bone density, among the stable morphological structures of the maxilla and enriches knowledge with quantitative morphology and becomes a guide for further research and prenatal diagnostics of fetal development as well. We find it promising to carry out the research on mineral content and density of bone tissue of pathologically altered upper jaws of pre-fetuses, human fetuses, newborns and to study their development under conditions of external factors in ecologically unfavorable regions.

Author Biographies

A.P. Oshurko

Oshurko Anatolii Pavlovich – Post-graduate Student of the Department of Histology, Cytology and Embryology of Higher State Educational Institution of Ukraine “Bukovinian State Medical University” in Chernivtsi, Teatralna square 2, 58002, Chernivtsi, Ukraine; ORCID iD 0000-0002-3838-2206;

I.Yu. Oliinyk

Oliinyk Ihor Yuriyovych – MD, Professor of the Department of Pathological Anatomy of Higher State Educational Institution of Ukraine “Bukovinian State Medical University” in Chernivtsi, Teatralna square 2, 58002, Chernivtsi, Ukraine; ORCID iD 0000-0002-6221-8078.

References

1. Daxno, L. O., Krynyczkyj, R. P., Pavliv, X. I., Masna, Z. Z. & Masna-Chala, O. Z. (2014). Osoblyvosti perebudovy komirkovyx vidrostkiv shhelep ta yix spivvidnoshennya z korenyamy postijnyx zubiv u vikovomu aspekti [Features of rearrangement of collar processes of the jaws and their correlation with the roots of permanent teeth in the age aspect]. Visnyk problem biologiyi i medycyny - Bulletin of Biology and Medicine, 2 (1), 136–139.

2. Korchynska, N. S., Slobodyan, O. M. & Vacyk, M. M. (2017). Perynatalna anatomiya komirkovogo vidrostka verxnoyi shhelepy [Perinatal anatomy of the alveolar process of the upper jaw]. Svit medycyny ta biologiyi – World of Medicine and Biology, 2 (60), 139–143.

3. Mishalov, V. D., Voichenko, V. V., Malysheva, T. A., Dibrova, V. A., Kuzyk, P. V. & Yurchenko, V. T. (2018). Poriadok vyluchennia biolohichnykh obiektiv vid pomerlykh, tila yakykh pidliahaiut sudovo-medychnii ekspertyzi i patolohoanatomichnomu doslidzhenniu, dlia naukovykh tsilei: metodychni rekomendatsii [The procedure for the removal of biological objects from the dead, the bodies of which are subject to forensic examination and pathologoanatomical research, for scientific purposes: methodical recommendations]. Osvita Ukrainy: spetsvypusk hazety. Kyiv: Pedahohichna presa – Education of Ukraine: special issue of the newspaper. Kiev: pedagogical press, 2 (62), 3–13.

4. Mishalov, V. D., Chajkovs`kyj, Yu. B. & Tverdoxlib, I. V. (2007). Pro pravovi, zakonodavchi ta etychni normy i vymogy pry vykonanni naukovyx morfologichnyx doslidzhen [On legal, legislative and ethical norms and requirements in the course of scientific morphological research]. Morfologiya – Morphology, 1 (2), 108–115. Vzyato z http://www.morphology.dp.ua/_pub/MORPHO-2007-01-02/07mvdnmd.

5. Oshurko, A. P. & Olijnyk, I. Yu. (2017). Morfogenez verxnoyi shhelepy ta pryleglyx struktur shhelepo-lycevoyi dilyanky v peredplodiv lyudyny` 7–9 tyzhniv vnutrishnoutrobnogo rozvytku [Morphogenesis of the upper jaw and adjacent structures of the jaw-facial area in prenatal human 7–9 weeks of intrauterine development]. Ukrayinskyj zhurnal medycyny, biologiyi ta sportu – Ukrainian Journal of Medicine, Biology and Sports, 4 (6), 26–35.

6. Pogoryelov, M. V. (2017). Regional`ni vidminnosti mineral`nogo skladu v stinci sercya lyudy`ny` uprodovzh ontogenezu [Regional differences in the mineral composition in the human heart wall during ontogenesis]. Morfologiya – Morphology, 11 (2), 25–27. Vzyato z http://nbuv.gov.ua/UJRN/Morphology_2017_11_2_6.

7. Ponomarenko, S. I. (2015). Zviazok mizh parametramy stomatolohichnoho statusu ta systemnymy pokaznykamy stanu kistkovoi systemy [Relationship between the parameters of the dental status and the systemic indicators of the state of the bone system]. Problemy osteolohii – Problems of osteology, 18 (2), 40–50.

8. Chaikovska, S. Yu. (2016). Analiz vikovoi dynamiky mineralnoho skladu kistkovoi tkanyny komirkovoi chastyny nyzhnoi shchelepy u ditei doshkilnoho viku [Analysis of age dynamics of mineral composition of bone tissue of the cellular part of the mandible in preschool children]. Klinichna anatomiia ta operatyvna khirurhiia – Clinical Anatomy and Operative Surgery, 15 (3), 53–57.

9. Baumgart, M., Wiśniewski, M., Grzonkowska, M., Badura, M., Dombek, M., Małkowski, B. & Szpinda, M. (2016). Morphometric study of the two fused primary ossification centers of the clavicle in the human fetus. Surgical and Radiologic Anatomy, 38, 937–945. doi: 10.1007/s00276-016-1640-y.

10. Oshurko, A. P. & Oliinyk, I. Yu. (2019). Study of the qualitative characteristics of the maxilla bone tissue according to the quantitative content of macroelements (P, Na, Ca, Mg, S) in the dynamics of prenatal ontogenesis. World of Medicine and Biology, 1 (67), 171–177. doi: 10.26.724 / 2079-8334-2019-1-67-171.

11. Sant'Anna, E. F., Lau, G. W., Marquezan, M., de Souza Araújo, M. T., Polley, J. W. & Figueroa, A. A. (2015). Combined maxillary and mandibular distraction osteogenesis in patients with hemifacial microsomia. American Journal of Orthodontics and Dentofacial Orthopedics, 147 (5), 566–577. doi: 10.1016/j.ajodo.2014.12.027.

12. Szpinda, M., Baumgart, M., Szpinda, A., Woźniak, A., Małkowski, B., Wiśniewski, M., Mila-Kierzenkowska, C. & Króliczewski, D. (2013). Cross-sectional study of the ossification center of the C1–S5 vertebral bodies. Surgical and Radiologic Anatomy, 35, 395–402. doi: 10.1007/s00276-012-1045-5.
Published
2019-03-01
How to Cite
Oshurko, A., & Oliinyk, I. (2019). Results of 3-D reconstruction in dynamic analysis for determining the bone tissue density of the maxilla in human prenatal ontogenesis. Reports of Vinnytsia National Medical University, 23(1), 24-35. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2019-23(1)-04