Clinical and morphological features of crohn's disease with oral lesions


Keywords: chronic recurrent aphthous stomatitis, Crohn's disease, biopsy, granulomatous inflammation.

Abstract

The aim is to study the clinical and morphological features of Crohn's disease with damage to the oral cavity. The analysis of clinical and morphological features of Crohn's disease with oral lesions in 86 patients aged 18 to 65 years has been carried out. Patients with mucosal lesions of the oral cavity performed a biopsy with histological examination. The study of the intestine was performed using capsule endoscopy, colonoscopy with a biopsy of the affected sections of the intestine. The results of the study of the clinical and morphological features of Crohn's disease with oral lesions have shown that 33 (38.4%) patients experienced changes in the oral cavity, in particular, chronic recurrent aphthous stomatitis in 9 (10.46%) patients, at 19 (22.1%) of patients, symptoms of oral cavity appeared earlier intestinal manifestations, which is confirmed by the results of histological examination of the oral mucosa, namely the presence of granulomatous inflammation. The obtained results of intestinal studies by capsule endoscopy and colonoscopy with biopsy of affected areas of distal departments of the ileum and the intestine also confirm the presence of granulomatous changes from the mucous membrane of the large intestine corresponding to the diagnosis of Crohn's disease. Characteristic morphological changes of the affected mucosa of the oral cavity during Crohn's disease are granulomatous inflammation, which correlates with changes in the mucous membrane of the ileum and cecum.

Author Biographies

O. Dyadyk

Dyadyk Olena Oleksandrivna – professor, MD, Dr. Sci, Head of the Department of Pathological and Topographic Anatomy of Shupyk National Medical Academy of Postgraduate Education. Address: Kyiv, Dorogozhycka str, 9, phone: (044) 483-86-63, pathology-nmapo@ukr.net

O. Feleshtynska

Feleshtynska Oksana Iaroslavivna – PhD student of the Department of Dentistry of the Institute of Dentistry of Shupyk National Medical Academy of Postgraduate Education. Address: Kyiv, Dorogozhycka str, 9, phone: (067) 281-25-61, feleshtynska@gmail.com

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Published
2019-03-01
How to Cite
Dyadyk, O., & Feleshtynska, O. (2019). Clinical and morphological features of crohn’s disease with oral lesions. Reports of Vinnytsia National Medical University, 23(1), 20-23. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2019-23(1)-03