Levels of TNF-α and IL-8 in patients with acute and chronic pancreatitis
The aim of the study was to research levels of TNF-α and IL-8 in patients with acute and chronic pancreatitis. The study included 86 patients with a confirmed diagnosis of acute edematous pancreatitis (group 1) and 36 patients with a confirmed diagnosis of chronic pancreatitis (group 2). Control group consisted of 70 conditionally healthy people, in whom laboratory and instrumental indices were determined similar to those in patients with acute and chronic pancreatitis. According to the aim and objectives of the study, we analyzed the levels of amylase, lipase, TNF-α and IL-8. The data was processed using the SPSS 20.0 statistical software package for Windows. Determined that the level of amylase in group 1 was significantly (p<0.01) different from the same indicator in group 2 and in the control group. A similar trend was observed in the study of lipase levels in all groups. At the same time, there was no significant difference between the indicators of group 2 and the control group (p>0.05). Regarding the levels of TNF-α, its highest rates were observed in group 1. In a statistical analysis, it turned out that the level of TNF-α was significantly higher (p<0.05) in group 1 than in group 2 and the control group. The levels of IL-8 both in group 1 and group 2 were significantly higher (p<0.01) than in the control group. At the same time, the value of this indicator also differed significantly in the statistical comparison of groups 1 and 2. Thus, in acute pancreatitis, the levels of TNF-α were significantly higher (p<0.05) than in chronic pancreatitis, but its concentration did not correlate with other studied parameters. IL-8 levels progressively increase with an increase in the degree of activity of the inflammatory process, both in acute and in chronic pancreatitis, and correlates with an increase in such indicators as amylase and lipase in the acute form of the disease.
2. Machicado, J. D. & Yadav, D. (2017). Epidemiology of Recurrent Acute and Chronic Pancreatitis: Similarities and Differences. Dig. Dis. Sci., 62 (7), 1683–1691. DOI: 10.1007/s10620-017-4510-5.
3. Shah, A. P., Mourad, M. M. & Bramhall, S. R. (2018) Acute pancreatitis: current perspectives on diagnosis and management. J. Inflamm. Res., 11, 77–85. DOI: 10.2147/JIR.S135751.
4. van Dijk, S. M., Hallensleben, N. D. L., van Santvoort, H. C., Fockens P., van Goor, H., Bruno, M. J. & Besselink, M. G. (2017). Acute pancreatitis: recent advances through randomised trials. Gut, 66 (11), 2024–2032. DOI: 10.1136/gutjnl-2016-313595.
5. Kirkegård, J., Mortensen, F. V. & Cronin-Fenton, D. (2017) Chronic Pancreatitis and Pancreatic Cancer Risk: A Systematic Review and Meta-analysis. Am. J. Gastroenterol., 112 (9), 1366–1372. DOI: 10.1038/ajg.2017.218.
6. Gupte, A., Goede, D., Tuite, R. & Forsmark, Ch. E. (2018). Chronic pancreatitis. BMJ, 361, k2126. DOI: https://doi.org/10.1136/bmj.k2126.
This work is licensed under a Creative Commons Attribution 4.0 International License.