Features of diagnosis of anemia in patients with chronic obstructive pulmonary disease


Keywords: chronic obstructive pulmonary diseases, anemia of chronic disease, iron deficiency anemia, soluble transferrin receptors, ferritin.

Abstract

Anemia in patients with chronic obstructive pulmonary disease requires differential diagnosis in order to verify their cause and the purpose of adequate treatment. The purpose of our work was to study the specialty of diagnosis of anemia in patients with chronic obstructive pulmonary disease. During the study, all patients were evaluated for erythrocyte indexes, color index of blood, serum iron, ferritin and soluble transferrin receptors. The analysis of the obtained results were performed by using SPSS-21 software using ANOVA analysis with Fischer test and Bonferroni correction, p<0,05 was considered statistically significant. As a result, it was found that in patients with chronic obstructive pulmonary disease with anemia of chronic disease, the content of serum iron and soluble transferrin receptors is within the reference values at the same time with high ferritin content, this anemia was normocytic and normochromic, and in patients with chronic obstructive pulmonary disease with iron deficiency anemia, the content of serum iron and ferritin is low, and the content of soluble transferrin receptors is elevated, this anemia was microcytic and hypochromic. Thus, in order to verify the type of anemia in patients with chronic obstructive pulmonary disease, it is necessary to determine the content of erythrocyte indexes, color index of blood, serum iron, ferritin, and soluble transferrin receptors, in further research it can be used to determine an adequate treatment regimen for these patients.

References

1. Unifikovanyi klinichnyi protokol pervynnoi ta vtorynnoi (spetsializovanoi) medychnoi dopomohy. Zalizodefitsytna anemiia [Unified clinical protocol of primary and secondary (specialized) medical aid. Iron deficiency anemia]. Nakaz Ministerstva okhorony zdorov’ia Ukrainy vid 02.11.2015 №709.

2. Boutou, A. K., Karrar, S., Hopkinson, N. S. & Polkey, M. I. (2013). Anemia and survival in chronic obstructive pulmonary disease: a dichotomous rather than a continuous predictor. Respiration,85,126–131.doi: 10.1159/000338792.

3. Chambellan, A., Coulon, S., Cavailles, A., Hermine, O. & Similowski, T. (2012). COPD and erythropoiesis: Interactions and consequences. Rev. Mal. Respir., 29, 213–31. doi: 10.1016/j.rmr.2011.12.004.

4. Cote, C., Zilberberg, M. D., Mody, S. H., Dordelly, L. J. & Celli, B. (2007). Hemoglobin level and it`s clinical impact in a cohort of patients with COPD. Eur. Respir. J., 29, 923–929. doi: 10.1183/09031936.00137106.

5. Fidan, A., Tokmak, M. & Kiral, N. (2010). Anemia in COPD and related factors. Chest, 138, 457A. doi: 10.1378/chest.10779.

6. Marković, M., Majkić-Singh, N. & Subota, V. (2005). Usefulness of soluble transferrin receptor and ferritin in iron deficiency and chronic disease. Scand. J. Clin. Lab. Invest., 65 (7), 571–576. doi: 10.1080/00365510500206542.

7. Portillo Carroz, K. (2007). Anemia in COPD: should it be taken into consideration? Arch. Bronconeumol, 43 (7), 392–398. doi: 10.1157/13107696.

8. Skikne, B. S., Punnonen, K., Caldron, P. H., Bennett, M. T., Rehu, M., Gasior, G. H. … Southwick, P. C. (2011). Improved differential diagnosis of anemia of chronic disease and iron deficiency anemia: A prospective multicentere valuation of soluble transferrin receptor and the sTfR/log ferritin index. Am. J. Hematol., 86, 923–927. doi: 10.1002/ajh.22108.

9. Weiss, G. & Goodnough, L. T. (2005). Anemia of chronic disease. N. Engl. J. Med., 352, 1011–1023. doi: 10.1056/NEJMra041809.
Published
2018-12-28
How to Cite
KovchunА., Kmyta, V., & Prystupa, L. (2018). Features of diagnosis of anemia in patients with chronic obstructive pulmonary disease. Reports of Vinnytsia National Medical University, 22(4), 621-625. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2018-22(4)-07