Features of lesion of the cardiovascular system in patients with acute brucellosis

  • Yelchin Mamed oglu Huseynov
  • O. Starzhynska VNMU named after M. I. Pirogov
Keywords: acute brucellosis, cardiovascular system


Heart damage in acute brucellosis can determine the severity of the disease, affect the quality of life of the patient and the prognosis of the disease as a whole. The purpose of the study is the integrated assessment of the cardiovascular system (CCS) in patients with acute brucellosis on the basis of clinical and instrumental examination results. 120 patients with acute brucellosis were examined, the average age of patients was 35.9±2.8 years. In order to assess the state of the CCS, all patients were registered with the electrocardiogram in 12 standard leads, blood pressure (BP), and echocardiography. Statistical processing of the results was carried out using “STATISTICA 6.0” using parametric and non-parametric methods for evaluating the obtained results. During the study, it was found that 77.50% of patients with acute brucellosis had certain signs of abnormalities in the work of the CCS. Among clinical manifestations cardialgia is dominated by a non-ischemic nature, a marked increase in the frequency of cardiac contractions and a decrease in the level of predominantly diastolic blood pressure. Electrocardiographic changes are characterized by a predominant disruption of the function of automatism. The tendency to rhythm disturbances is confirmed by the detection of ventricular arrhythmias in them, prolongation of QT interval in some patients. Diagnosed disturbances of ventricular repolarization process, along with other changes, can be evidence of myocardial damage and its structural transformations. There was also a tendency to increase the size of the left heart, reducing the contractile capacity of the left ventricle and formation of one third of patients with diastolic dysfunction, which may be evidence of changes in the myocardium due to systemic inflammation inherent in brucellosis. Consequently, in the vast majority of patients with acute brucellosis, there are signs of lesion of the CCS that can be detected already during the routine clinical examination.


1. Ahmedova, M. D. (2007). Immunnaya sistema u bolnyh brucellezom s kardiovaskulyarnymi narusheniyami (monografiya) [The immune system in patients with brucellosis with cardiovascular disorders (monograph)]. Moskva: Medicina.

2. Vasyuk, Yu. A., Yushuk, N. D. & Ahmedova, M. D. (2008). Elektrokardiograficheskaya ocenka funkcionalnogo sostoyaniya serdca u bolnyh ostrym brucellezom [Electrocardiographic assessment of the functional state of the heart in patients with acute brucellosis]. Vestnik novyh medicinskih tehnologij – Bulletin of new medical technologies, 2, 131–132.

3. Zubareva, E. V., Shuldyakov, A. A. & Trubeckov, A. D. (2007). Diastolicheskaya, sistolicheskaya funkciya serdca i sindrom endogennoj intoksikacii pri hronicheskom bruzelleze [Diastolic, systolic function of the heart and the syndrome of endogenous intoxication in chronic Bruselle]. Vesnik Sankt-Peterburgskoj gosudarstvennoj medicinskoj akademii im. I.I. Mechnikova – Vesnik of St. Petersburg State Medical Academy named after I.I. Mechnikov, 4, 169–173.

4. Magomedova, S.  A., Adilova, M.  A. & Gipaeva, G.  A. (2015). Funkcionalnoe sostoyanie serdechno-sosudistoj sistemy u bolnyh razlichnymi formami brucelleza [The functional state of the cardiovascular system in patients with various forms of brucellosis]. Pediatr – Pediatrician, VI (3), 36–40.

5. Reshetnikov, A. A., Shuldyakov, A. A. & Safonova, M. V. (2009). Variabelnost serdechnogo ritma u pacientov s hronicheskim brucellezom: osobennosti vegetativnoj regulyacii [Heart rate variability in patients with chronic brucellosis: peculiarities of vegetative regulation]. Saratovskij nauchno-medicinskij zhurnal – Saratov Medical Journal, 5 (4), 578–580.

6. Yushuk, M. D., Ahmedova, M.  D. & Magomedova, S.  A. (2010). Kliniko-instrumentalnaya i laboratornaya ocenka porazheniya miokarda u bolnyh ostrym brucellezom. Epidemiologiya i infekcionnye bolezni – Epidemiology and Infectious Diseases, 1, 45–48.

7. Baddour, L. M., Wilson, W. R. Bayer, A. S., Fowler, V. G. Jr., Bolger, A. F., Levison, M. E. … Taubert, K. A. (2005). Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: endorsed by the Infectious Diseases Society of America. Circulation, 111 (23), Retrieved from 394–434. https://www.ncbi.nlm.nih.gov/pubmed/15956145.

8. Jia, B., Zhang, F., Pang, P., Zhang, T., Zheng, R., Zhang, W. … Ding, J. (2017). Brucella endocarditis: Clinical features and treatment outcomes of 10 cases from Xinjiang, China. J Infect., 74 (5), 512–514. doi: 10.1016/j.jinf.2017.01.011.

9. Mahjoub, M., Hassine, M., Boussaada, M., Ben Messaoud, M. & Cheniti, G. (2016). Brucellosis as an Unusual Cause of Mitral Infective Endocarditis. J. Cardiol. Curr. Res., 5 (1), 00149. DOI: 10.15406/jccr.2016.05.00149.

10. Sabzi, F., Heidari, A. & Faraji, R. (2017). Right ventricular outflow tract endocarditis caused by brucellosis. J. Infect. Public. Health, 10 (5), 678–680. doi: 10.1016/j.jiph.2016.09.010.

11. Tay, B. Y., Kandavello, G., Ahmad, N., Hashim, R., Mohd Zahidi, J., Md Shahit, S. S. … Dahalan, N. A. (2017). Infective endocarditis caused by Brucella melitensis: a case report highlighting the importance of history taking and laboratory analysis. Tropical Biomedicine, 34 (4), 970–976.

12. Zheng, R., Xie, S., Lu, X., Sun, L., Zhou, Y., Zhang, Y. & Wang, K. (2018). A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China. BioMed Research International., ID: 5712920, 1–10. doi: 10.1155/2018/5712920.

13. Zorlu, G., Uyar, S., Ozer, H., Esin, M., Kir, S., Tokuc, A. … Cekin, A. H. (2016). A case of brucellosis with a rare complication: pericarditis. EJCRIM, 3, doi:10.12890/2016_000471.
How to Cite
Huseynov, Y. M. oglu, & Starzhynska, O. (2018). Features of lesion of the cardiovascular system in patients with acute brucellosis. Reports of Vinnytsia National Medical University, 22(4), 616-620. https://doi.org/https://doi.org/10.31393/reports-vnmedical-2018-22(4)-06