Research to antimicrobial action characteristics of antiseptics under protein loading to microorganisms
Setting of rational antibacterial therapy for treatment of the used for setting fire diseases of oral cavity and throat is the issue enough of the day, the decision of that depends on the row of factors that cause implicit interest of practical medicine. Infectious diseases and purulent-inflammatory processes of microbial origin play an important role in shaping the main indicators of health in Ukraine. Unfortunately, the use of systemic antimicrobial drugs by doctors, in most cases, is empirical, without taking into account regional tendencies of resistance. It can promote the spread of strains of microorganisms with multiple resistance to them, the emergence of outbreaks of hospital infections and increase the risk of severe complications. The aim of this work is to investigate the antimicrobial activity of antiseptic drugs such as septefril, sebidin, agisept on clinical strains of S.aureus. The experiment made in presence of the unfavorable factors (5% and 10 % protein solution). Domestic antiseptic drug septefril in its composition antiseptic decamethoxin®. The basis of the drug itself is chlorhexidine. The basis of the drug agisept is amylmetacresol. The antimicrobial activity of the agisept at 5% protein loading practically did not change. Reduction of anti-staphylococcal activity by 2.3 times observed in the preparation of septefril. The highest decrease in activity observed 6 times in the drug itself. At 10% protein load, the antistaphylococcal activity decreased by seventh-one times in septefril, 1.3 times in agisept. The greatest decrease in activity, in 10.7 times, was at the same time. Thus, we have established a reduction in the antimicrobial activity of antiseptic drugs in the presence of serum protein, but the level of action remained quite high with respect to clinical strains of microorganisms.
2. Zhorniak, O. I., Divinski, D. M, & Stukan, O. K. (2016). Vplyv bilkovoho navantazhennia na antymikrobnu aktyvnist antyseptychnykh preparativ [Influence of protein load on antimicrobial activity of antiseptic drugs]. Biomedical and Biosocial Anthropology, 26, 118–121.
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