Analysis of some homocysteine contradictions

  • N.V. Zaichko
  • D.O. Nekrut
  • M.B. Lutsyuk
  • M.A. Artemchuk
Keywords: hyperhomocysteinemia, cardiovascular pathology, therapy with vitamins B6, B9, B12.


The existence of contradictory data in the literature and the lack of convincing evidence of the causes of hyperhomocysteinemia syndrome (HHC) associated with the disease give opposing views to the practical significance of high levels of homocysteine (HC) in plasma in patients. The article is written for the aim of having theoretical analysis of ambiguous, sometimes paradoxical data, on the problem of HHC, on the example of its association with cardiovascular pathology (CVP). The following paradoxes are formulated. The first paradox: in the part of clinical work, there was no link between moderate HHC and the risk of CVP. The second paradox: the prescription of vitamin B6, B9, B12 to patients for the prevention and treatment of CVP is usually accompanied by a significant reduction in the level of HC in plasma, but is not always realized by a decrease in the number of cardiovascular events. The third paradox: the mechanisms of the occurrence of HHC have not yet been identified in people with CVP or other diseases that correlate with the level of HC. Exceptions are only cases of these people having insufficient vitamins B6, B9, B12 taking part in the exchange of HC, or congenital defects of enzymes metabolism HC. The fourth paradox: in contrast to controversial clinical research, the results of experimental work are virtually unequivocal - artificial HHC pathogenetically associated with the development of CVP and other types of associated pathology. Thus, analysis of literary sources suggests the existence of opposing opinions, especially clinicians, about the role of HHC in the formation of cardiovascular pathology and the benefits of hypohomocysteinemic therapy. We believe that a definite value for the explanation of the contradictions will be focused research in the following areas: a) whether an increased level of HC is a cause, marker or consequence of cardiovascular disease; and b) whether HC is only a passive intermediate catabolism product of methionine or a biologically active compound with specific metabolic functions, the violation of which may take place both in the HHC, as well as due to hypohomocysteinemic therapy.


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How to Cite
Zaichko, N., Nekrut, D., Lutsyuk, M., & Artemchuk, M. (2018). Analysis of some homocysteine contradictions. Reports of Vinnytsia National Medical University, 22(1), 233-237.