Search for prognostic markers of heart failure in patients with clinically suspected myocarditis
Prediction of myocarditis clinical course remains one of the most challenging problems in present cardiology. The purpose of the study was to build the prognostic model of persistent heart failure and to detect its early predictors in patients with myocarditis. We established the following predictors of sustained HF: high concentration of CD16+ cells, high antimyocardial antibody titer and pronounced blasttransformation lymphocyte activity, presence of non-sustained ventricular tachycardia, impairment of left ventricular (LV) ejection fraction and longitudinal global systolic strain, increased LV end-diastolic volume index, and presence of typical changes on cardiac magnetic-resonance imaging observed on the 1st month after the diseaseonset. By the use of discriminant analysis a prognostic model was built that is characterized by high sensitivity and specificity andcould be used on the 1st month after myocarditis onset for the early prediction of HF persistence after 12 months of follow-up.