Effect of amantadine hydrochloride for the intensification of proliferative processes in the inferior alveolar nerve in its experimental compression-toxic iatrogenic lesions at changing titers neuromarker protein S100


  • A.V. Pogorila
  • М.М. Shinkaruk-Dykovytska
  • A.A. Khodakovsky
Keywords: iatrogenic compression-toxic inferior alveolar nerve lesions, protein S100, neuroprotection, amantadine hydrochloride

Abstract

The sealing materials based on resorcin-formaldehyde ("Foredent") or epoxy resin ("AH-Plus") has been enters in trepanation hole, which is located on the lower jaw projected inferior alveolar nerve, initiated destructive, degenerative changes, which is showed the increasing protein S100. Neomidantan the dose of 10 mg/kg intragastrically, contributed to the reduction in the blood serum titers S100 protein relative to control animal diseases in average 1,84 ("Foredent") and 1,71 ("AH-Plus") time that indicates the presence of this neuroprotection drug activity. Neomidantan (amantadine sulfate) can be used for a new purpose in the compression-toxic iatrogenic lesions of the inferior alveolar nerve, which is a promising and needsclinical confirmation of its effectiveness.

Published
2017-09-29
How to Cite
Pogorila, A., Shinkaruk-DykovytskaМ., & Khodakovsky, A. (2017). Effect of amantadine hydrochloride for the intensification of proliferative processes in the inferior alveolar nerve in its experimental compression-toxic iatrogenic lesions at changing titers neuromarker protein S100. Reports of Vinnytsia National Medical University, 20(2), 363-366. Retrieved from https://reports-vnmedical.com.ua/index.php/journal/article/view/383