Structural and functional indicators of myocardium in men citizens of Podillia region in Ukraine with essential hypertension stage II carriers of different variants of the brain natriuretic peptide gene


  • Yu.P. Pashkovа
  • H.O. Palahniuk
  • V.M. Zhebel
Keywords: essential hypertension, gene polymorphism of the brain natriuretic peptide, left ventricular hypertrophy

Abstract

It was investigated the features of structural and functional state of myocardium in carriers of different variants of the brain natriuretic peptide gene in men with essential hypertension stage II and left ventricular hypertrophy, citizens of Podillia region in Ukraine. Genotyping of the gene BNP was performed using polymerase chain reaction. Indicators of structural state of myocardium was assessed by ultrasound of the heart on the device "Biomedica Sim 5000 plus" (Italy). It was found that in men with essential hypertension stage II dominated the genotype Т381С and C allele of the BNP gene. In carriers of the genotype Т381Т of the BNP gene sizes and volumes of the left ventricle was significantly higher than in carriers of C allele of the BNP gene, which may indicate the adaptive processes in the functioning of the heart in high blood pressure. Among male patients with essential hypertension stage II, regardless of the carrier variant of the BNP gene dominated by individuals with concentric and moderate left ventricular hypertrophy. Among men with essential hypertension stage II most common registered hypertrophic type transmitral flow regardless of the carrier variant of the BNP gene.

Published
2017-09-29
How to Cite
PashkovаY., Palahniuk, H., & Zhebel, V. (2017). Structural and functional indicators of myocardium in men citizens of Podillia region in Ukraine with essential hypertension stage II carriers of different variants of the brain natriuretic peptide gene. Reports of Vinnytsia National Medical University, 20(1(2), 165-171. Retrieved from https://reports-vnmedical.com.ua/index.php/journal/article/view/331