Working-out of pathogenetic models of aseptic and infected acute pancreatitis
The data received in experimental study on development of pathogenetic models of aseptic and infected acute pancreatitis in rats are presented in this article. Modeling of acute aseptic pancreatitis was performed by intraparenchymal injection of the pancreatic enzymes. Infection was made by entering of suspension of content of the small intestine into analog of omental bag. Results of the experiment were estimated on 1st, 3rd, 7th day macroscopically, microscopically and using the results of biochemical study. Proposed experimental models of aseptic and infected acute pancreatitis are pathogenetically adequate. They cause typical morphological and biochemical changes and they could be recommended for using during the study of new experimental approaches to the treatment of acute pancreatitis.