New approaches to correct genitals microbiota disorders in women with hyperproliferative diseases of the uterus and cervical pathology
We examined 110 patients (І group - 40 women with uterine leiomyoma and chronic salpingitis (CS), ІІ group - 40 women with leiomyoma in combination with adenomyosis and CS, ІІІ group - 30 women with CS). The violation of genital microbiocenosis was found in patients of all groups. The correcting effect of the drug benzydamine hydrochloride was evaluated on the performance of viral and bacterial contamination of the cervical canal (CC) (14 days after completion of therapy). We established positive effect of benzydamine hydrochloride on CC microbiocenosis in all patient groups (in 77.7% patients of group I we registered decrease in inoculation level of potentially pathogenic microbiota, Candida fungi and Gardnerella on the background of restored lacto-flora level and decrease of viral infections). In patients from group II with cervical pathologies (LSIL and HSIL) we noted after treatment the tendency to normalization in CC microbiocenosis: normalized inoculation results for Staphylococcus aureus and Staphylococcus epidermidis haemolysis type, as well as Candida fungi. After treatment 85.7% of women from group III demonstrated considerably increased protective microbiota level and normalized inoculation numbers of opportunistic pathogenic microbiota.