Efficacy of antibacterial action of antibiotics, antiseptic decametoxin and pseudomonal bacteriophage on clinical strains of pseudomonas aeruginosa


  • G.K. Paliy
  • I.M. Vovk
  • I.M. Kovalenko
  • O.A. Nazarchuk
  • V.M. Burkot
Keywords: decametoxine, pseudomonal bacteriophage, antibiotics, Pseudomonas aeruginosa

Abstract

This research presents results of combine action of decametoxin, antipseudomonal antibiotics and pseudomonal bacteriophage on clinical isolates of P.aeruginosa. It is shown that antiseptics decametoxin in dose up to 500?g/ml has no negative influence on bacteriophage activity. Subinhibitory concentration of decametoxin and antibiotics enhance lytic action of pseudomonal bacteriophage in vitro. Our results allow expecting high efficacy of combine treatment at pseudomonal infection with local preparations (specific phage, decamethoxin) and parenteral antimicrobial medicines (quinolones, antibiotics), and prevent development of phage resistance in clinical strains during medical care.

Published
2017-09-29
How to Cite
Paliy, G., Vovk, I., Kovalenko, I., Nazarchuk, O., & Burkot, V. (2017). Efficacy of antibacterial action of antibiotics, antiseptic decametoxin and pseudomonal bacteriophage on clinical strains of pseudomonas aeruginosa. Reports of Vinnytsia National Medical University, 20(1(1), 16-21. Retrieved from https://reports-vnmedical.com.ua/index.php/journal/article/view/295

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