Comorbid states in patients with infectious exacerbation of chronic obstructive pulmonary disease
The results of examination of 154 patients (59,1% of them were men) with average age of infectious exacerbation of chronic obstructive pulmonary disease (COPD) are presented. The majority of patients were found to have a severe course of COPD (64,29% - COPD stage III). ). Increase of disease severity was accompanied by the increased number of males reaching 80% in COPD stage IV. The patients were characterized by significant comorbidity: 92,9% of them had at least one concomitant disease. Males dominated among the patients with high comorbidity rate. The frequency of comorbidities increased with the progression of COPD. Cardiovascular diseases (angina - 22,3%, atrial fibrillation - 33.3%, hypertension stage II - 55,5%, heart failure II-III FC - 60,0%) and diabetes mellitus (26,7%) predominated in very severe COPD. Inverse relationship between FEV1 indices and levels of creatinine, transaminases, C-reactive protein as well as direct correlation between the level of FEV1 and glomerular filtration rate were established. The most significant clinical conditions associated with increased risk of death in COPD patients with severe ventilation insufficiency(FEV1<50%), by COTE index values, were coronary heart disease (40,0%), pulmonary fibrosis (28,0%) and congestive heart failure (17,0%).