Clinical and diagnostic value of brain-derived neurotrophic factor and interleukin-1β in patients with rheumatoid arthritis: relation to fibromyalgia
It was evaluated diagnostic and prognostic value of brain-derived neurotrophic factor (BDNF) and interleukin-1 β (IL- 1 β) in patients with rheumatoid arthritis (RA) in case of comorbidity with fibromyalgia (FM). It was found that the levels of BDNF and IL-1 β in serum were above 2.26 and 1.95 times higher in RA patients than in healthy individuals (p<0,001). Increased BDNF associated with FM markers - number of tender points, pain prevalence, psychological disturbances (p <0,01), and was not related to the activity of the inflammatory process. High serum levels of BDNF (>30 ng / mL) is a marker of central sensitization in patients with RA with a sensitivity of 71,7% and a specificity of 88,6%. High level of IL-1 β in the serum is an independent predictor of increased activity at the comorbidity RA with FM.