Analysis of the impact of propylene glycol extracts of medicinal plants and royal jelly on the manifestations of oxidative stress and antioxidant defense system in blood of rats with metabolic syndrome


  • N.O. Markhon
  • V.I. Zhyliuk
  • V.I. Mamchur
  • A.E. Lievykh
Keywords: experimental metabolic syndrome, propylene glycol extracts, lipid peroxidation, oxidative modification of proteins, blood

Abstract

Experimental modeling of metabolic syndrome (MetS) in white rats by complete replacement of drinking water by 60% fructose solution is accompanied by an increase of blood levels of free radical oxidation products of lipids (malondialdehyde) and proteins (aldehydephenylhydrazones and ketophenylhydrazones) as well as suppression of antioxidant defense (superoxide dismutase). It has been established that application of propylene glycol extracts (PGE) of nettle, raspberry, walnut, mountain ash and Royal jelly in the course of 14 days in rats with MetS reduces the manifestations of oxidative stress in varying degree in serum of experimental animals. The largest inhibition of the activity of free radical oxidation and increase in the activity of antioxidant defense system in animals with MetS was noted after administration of PGE of Royal jelly.

Published
2017-09-29
How to Cite
Markhon, N., Zhyliuk, V., Mamchur, V., & Lievykh, A. (2017). Analysis of the impact of propylene glycol extracts of medicinal plants and royal jelly on the manifestations of oxidative stress and antioxidant defense system in blood of rats with metabolic syndrome. Reports of Vinnytsia National Medical University, 19(2), 334-338. Retrieved from https://reports-vnmedical.com.ua/index.php/journal/article/view/234