Biochemical alterations in the brain and behavioral reactions in open field test in rats with homocysteine thiolactone-induced hyperhomocysteinemia


  • P.A. Yurchenko
  • N.V. Zaichko
Keywords: homocysteine, hydrogen sulfide, nucleotide metabolism, brain, behavioral reactions

Abstract

Biochemical alterations in the brain and behavioral reactions in open field test in rats with homocysteine thiolactoneinduced hyperhomocysteinemia (HHC) were investigated. The administration of homocysteine thiolactone caused a dose-dependent decrease of H2S levels, inhibition of the activity of nucleotide metabolism enzymes and the development of energy deficiency in the brain of rats. Unfavorable metabolic pattern in the brain was associated with disorders of orienting-exploratory activity and vegetative balance in open field test in rats with HHC.

Published
2017-09-29
How to Cite
Yurchenko, P., & Zaichko, N. (2017). Biochemical alterations in the brain and behavioral reactions in open field test in rats with homocysteine thiolactone-induced hyperhomocysteinemia. Reports of Vinnytsia National Medical University, 19(2), 330-333. Retrieved from https://reports-vnmedical.com.ua/index.php/journal/article/view/233