The morpho-functional state of the pancreas in the conditions of nitric oxide deficiency in rats in experiment
Non-specific inhibitor of NOs NG-nitro-L-arginine was administrated for the duration of the experiment, and the most significant changes (discirculation and dissecretion) were observed on the 12th day, whereupon the reaction slows due to a compensatory response. On the 30th day of experiment tiny bands of fibrous tissue were formed, which also evidenced by the increase of collagen synthesis markers in blood - protein-bound hydroxyproline (p<0,05). Incompetence of pancreatic cells was manifested by the reduced activity of pancreatic enzymes (p<0,05), and the visible hyposecretion of acinar cells on the morphological study. The maximum decrease of nitrite / nitrate concentration was observed after the first day (p<0,05), with a gradual increase to a maximum on 12-th day (p<0,05).