Application of “Betargin” in complex treatment of patients with the first diagnostic tubercolosis with toxic complications of antituburculosis therapy


  • O.P. Nezgoda
  • M.A. Tkhorovsky
  • O.V. Dublyansky
  • V.V. Mikhalchyshina
  • O.O. Zakharchenko
  • O. V. Plikanchuk
  • T.I. Klymenko
Keywords: side effects of anti-TB drugs, tuberculosis intoxication, “Betargin”.

Abstract

The aim of the work is to evaluate the effect of “Betargin” on the dynamics of clinical and biochemical parameters and to determine the feasibility of its use in patients with toxic side-effects for the treatment of tuberculosis with a clear toxicity syndrome. 38 patients with tuberculosis with toxic complications of chemotherapy were examined. Patients of the control group (CG) (20 persons) received standard antituberculous treatment. Patients of the main group (MG) (18 persons) received the agent “Betargin” in addition to this therapy. Evaluated clinical and laboratory parameters (blood test, levels of ALT, AST, bilirubin, total protein of blood). Manifestations of toxic adverse reactions in both groups have decreased. The dynamics of regression of complications of polychemotherapy was higher in MG patients. In 15 (83.0 %) patients with MG and 10 (50.0 %) of MG manifestations decreased, and in 13 (72.0 %) and 7 (35.0 %) respectively, the toxicity syndrome completely disappeared (p<0,05). Drowsiness decreased or disappeared in 14 (77.8 %) and 8 (40.0 %) patients respectively, increased fatigue — in 12 (66.7 %) and 3 (15.0 %). The levels of ALT and AST in MG by therapy decreased significantly (p<0,05) by 77.8 % and 61.1 % respectively; in CG the decreasing in these rates was less clear and was 35.0 % (ALT) and 15.0 % (AST). So, “Betargin” quickly eliminates the manifestations of astenovegetative and intoxication syndrome in the underlying disease, minimizes discomfort, improves appetite and general condition of patients. The use of “Betargin” in patients with tuberculosis improves clinical parameters, as well as data from laboratory and clinical research methods. The use of “Betargin” does not require the abolition of major anti-TB drugs, but is used in combination with them.

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Published
2017-09-29
How to Cite
Nezgoda, O., Tkhorovsky, M., Dublyansky, O., Mikhalchyshina, V., Zakharchenko, O., Plikanchuk, O. V., & Klymenko, T. (2017). Application of “Betargin” in complex treatment of patients with the first diagnostic tubercolosis with toxic complications of antituburculosis therapy. Reports of Vinnytsia National Medical University, 21(2), 440-444. Retrieved from https://reports-vnmedical.com.ua/index.php/journal/article/view/22