Influence of hydrogen sulfide on the analgesic and anti-inflammatry effects of diclofenac sodium in experiments
In experiments on rats and mice the influence of H2S on the analgesic and anti-inflammatory effects of diclofenac sodium was determined. Antinociceptive and antiphlogogenic effects of the donor of H2S (1,5 mg/kg i.p.), diclofenac (8 mg/kg i.g) and their combinations were studied during electric pain stimulation, formalin test and carrageenan edemas. It was established that donor of H2S minimizes inflammatory process, causes moderate antinociceptive effect at intact animals, and more significant analgesic effect under experimental inflammatory processes. Its injection increased analgesic and anti-inflammatory actions of diclofenac sodium. Thus, ability of H2S to modulate the pharmacodynamics of NSAIDs may be promising ways of increasing the effectiveness and safety of pharmacotherapy with drugs of this group.