Cholelithiasis in children with hereditary microspherocytosis

  • V. M. Dudnуk
  • V.G. Furman
Keywords: children, hemolytic anemia, сholelithiasis.


The clinical features of the main forms of cholelithiasis have been studied by a retrospective analysis of 46 histories of diseases of children aged 1 to 18 years who were on inpatient treatment in the oncohematological department in Vinnytsya regional children clinical hospital during 2009–2016 years. We found that damage of hepatobiliary system was observed in all children with hereditary spherocytosis hemolytic anemia. The distribution of children with hereditary spherocytosis, which have affected the hepatobiliary system, has shown that boys are more likely to be ill at the age of 12 to 18 years. Asymptomatic cholelithiasis was detected in 24 patients (52,2±3,0 %), pain form in 1/3 of patients, symptomatic gallstones form with biliary colic in 8 (17,4±1,1 %) patients. A significant increase in total bilirubin in all children with hereditary spherocytosis was noted in comparison with healthy children. In the group of children aged 12 to 16 years the activity of ALT is higher 20 % than in groups aged 1 to 6 years.


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How to Cite
DudnуkV. M., & Furman, V. (2017). Cholelithiasis in children with hereditary microspherocytosis. Reports of Vinnytsia National Medical University, 21(2), 410-413. Retrieved from