Cholelithiasis in children with hereditary microspherocytosis
The clinical features of the main forms of cholelithiasis have been studied by a retrospective analysis of 46 histories of diseases of children aged 1 to 18 years who were on inpatient treatment in the oncohematological department in Vinnytsya regional children clinical hospital during 2009–2016 years. We found that damage of hepatobiliary system was observed in all children with hereditary spherocytosis hemolytic anemia. The distribution of children with hereditary spherocytosis, which have affected the hepatobiliary system, has shown that boys are more likely to be ill at the age of 12 to 18 years. Asymptomatic cholelithiasis was detected in 24 patients (52,2±3,0 %), pain form in 1/3 of patients, symptomatic gallstones form with biliary colic in 8 (17,4±1,1 %) patients. A significant increase in total bilirubin in all children with hereditary spherocytosis was noted in comparison with healthy children. In the group of children aged 12 to 16 years the activity of ALT is higher 20 % than in groups aged 1 to 6 years.
2. Shadrin, O. G. & Shutova, E. V. (2013). Podhody k terapii rannej stadii zhelchnokamennoj bolezni u detej. Zdorove rebenka, 7, 92–95. Взято из http://nbuv.gov.ua/UJRN/perynatology_2013_4_24. [in Russian].
3. Abdullah, F., Zhang, Y., Camp, M., Rossberg, M. I., Bathurst, M. A., Colombani, P. M., … Chang, D. C. (2009). Splenectomy in Hereditary Spherocytosis: Review of 1,657 Patients and Application of the Pediatric Quality Indicators. Pediatr. Blood Cancer, 52(7), 834–837. doi: 10.1002/pbc.21954.
4. Bolton-Maggs, P. H., Langer, J. C., Iolascon, A., Tittensor, P. & King, M.J. (2012). Guidelines for the diagnosis and management of hereditary spherocytosis--2011 update. British Journal of Haematology, 156(1), 37–49. doi: 10.1111/j.1365-2141.2011.08921.x.
5. Crisp, R. L., Solari, L., Vota, D., García, E., Miguez, G., Chamorro, M. E. … & Donato, H. (2011). А prospective study to assess the predictive value for hereditary spherocytosis using five laboratory tests (cryohemolysis test, eosin-5′-maleimide flow cytometry, osmotic fragility test, autohemolysis test, and SDS-PAGE) on 50 hereditary spherocytosis families in Argentina. Ann. Hematol., 90(6), 625–634. doi: 10.1007/s00277-010-1112-0.
6. del Giudice, E.M., Perrotta, S., Nobili, B., Specchia, C., d'Urzo, G., Iolascon, A. (1999). Coinheritance of Gilbert Syndrome Increases the Risk for Developing Gallstones in Patients With Hereditary Spherocytosis. Blood., 94(7), 2259–2262.
7. Karami, H., Kianifar, H., Karami, S. (2017). Cholelithiasis in Children: A Diagnostic and Therapeutic Approach. Journal of Pediatric Review, 5(1), doi: 10.17795/jpr-9114.
8. Kumar, D., Parakh, A. & Sharma S. (2012). Gilbert syndrome increasing unconjugated hyperbilirubinemia in a child with hereditary spherocytosis. J. Pediatr Hematol. Oncol., 34(1), 54–56. doi: 10.1097/MPH.0b013e318228fdd1.
9. Mitsuhiko Aiso, Minami Yagi, Atsushi Tanaka, Kotaro Miura, Ryo Miura, Toshihiko Arizumi … & Hajime Takikawa (2017). Gilbert Syndrome with Concomitant Hereditary Spherocytosis Presenting with Moderate Unconjugated Hyperbilirubinemia. Internal medicine, 56(6), 661–664.
10. Perrotta, S., Gallagher, P. G. & Mohandas, N. (2008). Hereditary spherocytosis. Lancet, 372(9647), 1411–1426. doi: 10.1016/S0140-6736(08)61588-3.
11. Rocha, S., Costa, E., Ferreira, F., Cleto, E., Barbot, J., Rocha-Pereira, P. … & Santos-Silva, A. (2010). Hereditary spherocytosis and the (TA)nTAA polymorphism of UGT1A1 gene promoter region - comparison of the bilirubin plasmatic levels in the different clinical forms. Blood Cells, Molecules, and Diseases, 44(2), 117–119. doi: 10.1016/j.bcmd.2009.10.012.
12. Uday Y. H. Abdullah, Haitham M. Jassim, Atif A. Baig, Rana M. Khorsheed, Ali M. H. AL-Khayat, Ahmad F. B. Sulong … & Wisam A. (2015). Yassin Gallstones in patients with inherited hemolytic diseases. International Journal of Pharmacy and Pharmaceutical Sciences, 7(7), 9–15.
13. Van Erpecum, K. J. (2011). Pathogenesis of cholesterol and pigment gallstones: An update. Clinics and Research in Hepatology and Gastroenterology, 35(4), 281–287. doi: 10.1016/j.clinre.2011.01.009.
14. Vítek, L. & Carey, M. (2012). New pathophysiological concepts underlying pathogenesis of pigment gallstones. Clinics and Research in Hepatology and Gastroenterology, 36(2), 122–129. doi: 10.1016/j.clinre.2011.08.010.